Temporal organization of the cell cycle.
The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexit...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2008
|
| _version_ | 1797093194763075584 |
|---|---|
| author | Tyson, J Novak, B |
| author_facet | Tyson, J Novak, B |
| author_sort | Tyson, J |
| collection | OXFORD |
| description | The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place. |
| first_indexed | 2024-03-07T03:56:47Z |
| format | Journal article |
| id | oxford-uuid:c323d973-1dec-415c-a54d-eb2339c16448 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:56:47Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c323d973-1dec-415c-a54d-eb2339c164482022-03-27T06:14:17ZTemporal organization of the cell cycle.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c323d973-1dec-415c-a54d-eb2339c16448EnglishSymplectic Elements at Oxford2008Tyson, JNovak, BThe coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place. |
| spellingShingle | Tyson, J Novak, B Temporal organization of the cell cycle. |
| title | Temporal organization of the cell cycle. |
| title_full | Temporal organization of the cell cycle. |
| title_fullStr | Temporal organization of the cell cycle. |
| title_full_unstemmed | Temporal organization of the cell cycle. |
| title_short | Temporal organization of the cell cycle. |
| title_sort | temporal organization of the cell cycle |
| work_keys_str_mv | AT tysonj temporalorganizationofthecellcycle AT novakb temporalorganizationofthecellcycle |