Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country.
INTRODUCTION: Data on infective endocarditis (IE) in Southeast Asia are scarce. OBJECTIVES: To describe the clinical epidemiology of IE in Lao PDR, a lower middle-income country. METHODS: A single centre retrospective study at Mahosot Hospital, Vientiane. Patients aged over 1year of age admitted 200...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2015
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| _version_ | 1826295171279486976 |
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| author | Mirabel, M Rattanavong, S Frichitthavong, K Chu, V Kesone, P Thongsith, P Jouven, X Fournier, P Dance, D Newton, P |
| author_facet | Mirabel, M Rattanavong, S Frichitthavong, K Chu, V Kesone, P Thongsith, P Jouven, X Fournier, P Dance, D Newton, P |
| author_sort | Mirabel, M |
| collection | OXFORD |
| description | INTRODUCTION: Data on infective endocarditis (IE) in Southeast Asia are scarce. OBJECTIVES: To describe the clinical epidemiology of IE in Lao PDR, a lower middle-income country. METHODS: A single centre retrospective study at Mahosot Hospital, Vientiane. Patients aged over 1year of age admitted 2006-2012 to Mahosot Hospital with definite or possible IE by modified Duke criteria were included. RESULTS: Thirty-six patients fulfilled the inclusion criteria; 33 (91.7%) had left-sided IE. Eleven (30.6%) had definite IE and 25 (69.4%) possible left-sided IE. Median age was 25years old [IQR 18-42]. Fifteen patients (41.7%) were males. Underlying heart diseases included: rheumatic valve disease in 12 (33.3%), congenital heart disease in 7 (19.4%), degenerative valve disease in 3 (8.3%), and of unknown origin in 14 (38.9%) patients. Native valve IE was present in 30 patients (83.3%), and prosthetic valve IE in 6 patients (16.7%). The most frequent pathogens were Streptococcus spp. in 7 (19.4%). Blood cultures were negative in 22 patients (61.1%). Complications included: heart failure in 11 (30.6%), severe valve regurgitation in 7 (19.4%); neurological event in 7 (19.4%); septic shock or severe sepsis in 5 (13.9%); and cardiogenic shock in 3 patients (8.3%). No patient underwent heart surgery. Fourteen (38.9%) had died by follow-up after a median of 2.1years [IQR 1-3.2]; and 3 (8.3%) were lost to follow-up. CONCLUSIONS: Infective endocarditis, a disease especially of young adults and mainly caused by Streptococcus spp., was associated with rheumatic heart disease and had high mortality in Laos. |
| first_indexed | 2024-03-07T03:56:56Z |
| format | Journal article |
| id | oxford-uuid:c331937e-37b0-486e-8bc5-1d982b509571 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:56:56Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:c331937e-37b0-486e-8bc5-1d982b5095712022-03-27T06:14:39ZInfective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c331937e-37b0-486e-8bc5-1d982b509571EnglishSymplectic Elements at OxfordElsevier2015Mirabel, MRattanavong, SFrichitthavong, KChu, VKesone, PThongsith, PJouven, XFournier, PDance, DNewton, PINTRODUCTION: Data on infective endocarditis (IE) in Southeast Asia are scarce. OBJECTIVES: To describe the clinical epidemiology of IE in Lao PDR, a lower middle-income country. METHODS: A single centre retrospective study at Mahosot Hospital, Vientiane. Patients aged over 1year of age admitted 2006-2012 to Mahosot Hospital with definite or possible IE by modified Duke criteria were included. RESULTS: Thirty-six patients fulfilled the inclusion criteria; 33 (91.7%) had left-sided IE. Eleven (30.6%) had definite IE and 25 (69.4%) possible left-sided IE. Median age was 25years old [IQR 18-42]. Fifteen patients (41.7%) were males. Underlying heart diseases included: rheumatic valve disease in 12 (33.3%), congenital heart disease in 7 (19.4%), degenerative valve disease in 3 (8.3%), and of unknown origin in 14 (38.9%) patients. Native valve IE was present in 30 patients (83.3%), and prosthetic valve IE in 6 patients (16.7%). The most frequent pathogens were Streptococcus spp. in 7 (19.4%). Blood cultures were negative in 22 patients (61.1%). Complications included: heart failure in 11 (30.6%), severe valve regurgitation in 7 (19.4%); neurological event in 7 (19.4%); septic shock or severe sepsis in 5 (13.9%); and cardiogenic shock in 3 patients (8.3%). No patient underwent heart surgery. Fourteen (38.9%) had died by follow-up after a median of 2.1years [IQR 1-3.2]; and 3 (8.3%) were lost to follow-up. CONCLUSIONS: Infective endocarditis, a disease especially of young adults and mainly caused by Streptococcus spp., was associated with rheumatic heart disease and had high mortality in Laos. |
| spellingShingle | Mirabel, M Rattanavong, S Frichitthavong, K Chu, V Kesone, P Thongsith, P Jouven, X Fournier, P Dance, D Newton, P Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country. |
| title | Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country. |
| title_full | Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country. |
| title_fullStr | Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country. |
| title_full_unstemmed | Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country. |
| title_short | Infective endocarditis in the Lao PDR: clinical characteristics and outcomes in a developing country. |
| title_sort | infective endocarditis in the lao pdr clinical characteristics and outcomes in a developing country |
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