T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters.

T lymphocytes need less than 3 min to discriminate between peptide MHCs with similar TCR-binding parameters.

T lymphocytes need to detect rare cognate foreign peptides among numerous foreign and self-peptides. This discrimination seems to be based on the kinetics of TCRs binding to their peptide-MHC (pMHC) ligands, but there is little direct information on the minimum time required for processing elementar...

书目详细资料
Main Authors:	Brodovitch, A, Shenderov, E, Cerundolo, V, Bongrand, P, Pierres, A, van der Merwe, P
格式:	Journal article
语言:	English
出版:	Wiley 2015

相似书籍

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.
由: Zhengyu Ma, et al.
出版: (2008-02-01)

Machine learning optimization of peptides for presentation by class II MHCs
由: Dai, Zheng, et al.
出版: (2021)

1539 SARS-CoV-2 genome-wide single-chain-trimer peptide-MHCs reveal CD8+ T cell landscape in COVID-19 patients and distinct TCR repertoire dynamics
由: James Heath, et al.
出版: (2023-11-01)

Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
由: Minting Wen, et al.
出版: (2023-07-01)

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis
由: William Chour, et al.
出版: (2023-05-01)

Identification of pseudomonas aeruginosa via fast PCR in less than 5min
由: Lee, Soon Hong
出版: (2017)

Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination
由: Ana C Chang-Gonzalez, et al.
出版: (2024-01-01)

The TCR triggering puzzle.
由: Van Der Merwe, P
出版: (2001)

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.
由: Burroughs, N, et al.
出版: (2006)

Determination of the lifetime and force dependence of interactions of single bonds between surface-attached CD2 and CD48 adhesion molecules.
由: Pierres, A, et al.
出版: (1996)

The dependence of the association rate of surface-attached adhesion molecules CD2 and CD48 on separation distance.
由: Pierres, A, et al.
出版: (1997)

Membrane dynamics shape TCR-generated signaling
由: Hai-Tao eHe, et al.
出版: (2012-04-01)

TCR binding to peptide-MHC stabilizes a flexible recognition interface.
由: Willcox, B, et al.
出版: (1999)

Force and affinity in ligand discrimination by the TCR.
由: Depoil, D, et al.
出版: (2014)

Critically buried avalanche victims can develop severe hypothermia in less than 60 min
由: Simon Rauch, et al.
出版: (2023-06-01)

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.
由: Aleksic, M, et al.
出版: (2010)

TCR–pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding
由: Limozin, L, et al.
出版: (2019)

Generation and characterization of HLA-A2 transgenic mice expressing the human TCR 1G4 specific for the HLA-A2 restricted NY-ESO-1157-165 tumor-specific peptide
由: Vincenzo Cerundolo, et al.
出版: (2021-06-01)

Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism.
由: Bachmann, M, et al.
出版: (1998)

The kinetic-segregation model: TCR triggering and beyond.
由: Davis, S, et al.
出版: (2006)

TCR triggering: co-receptor-dependent or -independent?
由: Davis, S, et al.
出版: (2003)

The kinetic-segregation model: TCR triggering and beyond
由: Davis, S, et al.
出版: (2006)

Cell fitting to adhesive surfaces: A prerequisite to firm attachment and subsequent events
由: A Pierres, et al.
出版: (2002-06-01)

Cell fitting to adhesive surfaces: A prerequisite to firm attachment and subsequent events
由: Pierres A., et al.
出版: (2002-06-01)

CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex
由: Beatriz Garcillán, et al.
出版: (2021-06-01)

Enhancing TCR specificity predictions by combined pan- and peptide-specific training, loss-scaling, and sequence similarity integration
由: Mathias Fynbo Jensen, et al.
出版: (2024-03-01)

1,2,3, MHC: a review of mass-spectrometry-based immunopeptidomics methods for relative and absolute quantification of pMHCs
由: Stopfer, LE, et al.
出版: (2023)

1,2,3, MHC: a review of mass-spectrometry-based immunopeptidomics methods for relative and absolute quantification of pMHCs
由: L.E. Stopfer, et al.
出版: (2021-10-01)

Improving quality of care in less than 1 min: a prospective intervention study on postoperative handovers to the ICU/PACU
由: Sascha Treskatsch, et al.
出版: (2020-05-01)

TCR Fingerprinting and Off-Target Peptide Identification
由: Armen R. Karapetyan, et al.
出版: (2019-10-01)

Force measurements of TCR/pMHC recognition at T cell surface.
由: Pierre-Henri Puech, et al.
出版: (2011-01-01)

NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
由: Alessandro Montemurro, et al.
出版: (2021-09-01)

Grasping Discriminates between Object Sizes Less Not More Accurately than the Perceptual System
由: Frederic Göhringer, et al.
出版: (2019-07-01)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
由: Minh Ngoc Duong, et al.
出版: (2019-11-01)

DYNAMICS AND SELF-SIMILARITY IN MIN-DRIVEN CLUSTERING
由: Menon, G, et al.
出版: (2010)

Pairwise local structural alignment of RNA sequences with sequence similarity less than 40%.
由: Havgaard, J, et al.
出版: (2005)

Native and non-native plants provide similar refuge to invertebrate prey, but less than artificial plants.
由: Bart M C Grutters, et al.
出版: (2015-01-01)

HeteroTCR: A heterogeneous graph neural network-based method for predicting peptide-TCR interaction
由: Zilan Yu, et al.
出版: (2024-06-01)

On TCR binding predictors failing to generalize to unseen peptides
由: Filippo Grazioli, et al.
出版: (2022-10-01)

Targeting cancers through TCR-peptide/MHC interactions
由: Qinghua He, et al.
出版: (2019-12-01)