Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.
Repo-Man targets protein phosphatase 1 γ (PP1γ) to chromatin at anaphase onset and regulates chromosome structure during mitotic exit. Here, we show that a Repo-Man:PP1 complex forms in anaphase following dephosphorylation of Repo-Man. Upon activation, the complex localizes to chromosomes and causes...
Main Authors: | Vagnarelli, P, Ribeiro, S, Sennels, L, Sanchez-Pulido, L, de Lima Alves, F, Verheyen, T, Kelly, D, Ponting, C, Rappsilber, J, Earnshaw, W |
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Format: | Journal article |
Sprog: | English |
Udgivet: |
2011
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