Reconfigurable, braced, three-dimensional DNA nanostructures.
DNA nanotechnology makes use of the exquisite self-recognition of DNA in order to build on a molecular scale. Although static structures may find applications in structural biology and computer science, many applications in nanomedicine and nanorobotics require the additional capacity for controlled...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826295191485546496 |
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| author | Goodman, R Heilemann, M Doose, S Erben, C Kapanidis, A Turberfield, A |
| author_facet | Goodman, R Heilemann, M Doose, S Erben, C Kapanidis, A Turberfield, A |
| author_sort | Goodman, R |
| collection | OXFORD |
| description | DNA nanotechnology makes use of the exquisite self-recognition of DNA in order to build on a molecular scale. Although static structures may find applications in structural biology and computer science, many applications in nanomedicine and nanorobotics require the additional capacity for controlled three-dimensional movement. DNA architectures can span three dimensions and DNA devices are capable of movement, but active control of well-defined three-dimensional structures has not been achieved. We demonstrate the operation of reconfigurable DNA tetrahedra whose shapes change precisely and reversibly in response to specific molecular signals. Shape changes are confirmed by gel electrophoresis and by bulk and single-molecule Förster resonance energy transfer measurements. DNA tetrahedra are natural building blocks for three-dimensional construction; they may be synthesized rapidly with high yield of a single stereoisomer, and their triangulated architecture conveys structural stability. The introduction of shape-changing structural modules opens new avenues for the manipulation of matter on the nanometre scale. |
| first_indexed | 2024-03-07T03:57:15Z |
| format | Journal article |
| id | oxford-uuid:c34ae51b-e514-4904-a952-1c48bac7fd56 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:57:15Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c34ae51b-e514-4904-a952-1c48bac7fd562022-03-27T06:15:21ZReconfigurable, braced, three-dimensional DNA nanostructures.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c34ae51b-e514-4904-a952-1c48bac7fd56EnglishSymplectic Elements at Oxford2008Goodman, RHeilemann, MDoose, SErben, CKapanidis, ATurberfield, ADNA nanotechnology makes use of the exquisite self-recognition of DNA in order to build on a molecular scale. Although static structures may find applications in structural biology and computer science, many applications in nanomedicine and nanorobotics require the additional capacity for controlled three-dimensional movement. DNA architectures can span three dimensions and DNA devices are capable of movement, but active control of well-defined three-dimensional structures has not been achieved. We demonstrate the operation of reconfigurable DNA tetrahedra whose shapes change precisely and reversibly in response to specific molecular signals. Shape changes are confirmed by gel electrophoresis and by bulk and single-molecule Förster resonance energy transfer measurements. DNA tetrahedra are natural building blocks for three-dimensional construction; they may be synthesized rapidly with high yield of a single stereoisomer, and their triangulated architecture conveys structural stability. The introduction of shape-changing structural modules opens new avenues for the manipulation of matter on the nanometre scale. |
| spellingShingle | Goodman, R Heilemann, M Doose, S Erben, C Kapanidis, A Turberfield, A Reconfigurable, braced, three-dimensional DNA nanostructures. |
| title | Reconfigurable, braced, three-dimensional DNA nanostructures. |
| title_full | Reconfigurable, braced, three-dimensional DNA nanostructures. |
| title_fullStr | Reconfigurable, braced, three-dimensional DNA nanostructures. |
| title_full_unstemmed | Reconfigurable, braced, three-dimensional DNA nanostructures. |
| title_short | Reconfigurable, braced, three-dimensional DNA nanostructures. |
| title_sort | reconfigurable braced three dimensional dna nanostructures |
| work_keys_str_mv | AT goodmanr reconfigurablebracedthreedimensionaldnananostructures AT heilemannm reconfigurablebracedthreedimensionaldnananostructures AT dooses reconfigurablebracedthreedimensionaldnananostructures AT erbenc reconfigurablebracedthreedimensionaldnananostructures AT kapanidisa reconfigurablebracedthreedimensionaldnananostructures AT turberfielda reconfigurablebracedthreedimensionaldnananostructures |