Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans.
It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1826295200700432384 |
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| author | Elliott, A Kyosiimire, J Quigley, M Nakiyingi, J Watera, C Brown, M Joseph, S French, N Gilks, C Whitworth, J |
| author_facet | Elliott, A Kyosiimire, J Quigley, M Nakiyingi, J Watera, C Brown, M Joseph, S French, N Gilks, C Whitworth, J |
| author_sort | Elliott, A |
| collection | OXFORD |
| description | It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts > or = 0.4 x 10(9)/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined. |
| first_indexed | 2024-03-07T03:57:23Z |
| format | Journal article |
| id | oxford-uuid:c3552a42-1bb6-4aa9-ae6e-7d7c004487bd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:57:23Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:c3552a42-1bb6-4aa9-ae6e-7d7c004487bd2022-03-27T06:15:46ZEosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c3552a42-1bb6-4aa9-ae6e-7d7c004487bdEnglishSymplectic Elements at Oxford2003Elliott, AKyosiimire, JQuigley, MNakiyingi, JWatera, CBrown, MJoseph, SFrench, NGilks, CWhitworth, JIt has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts > or = 0.4 x 10(9)/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined. |
| spellingShingle | Elliott, A Kyosiimire, J Quigley, M Nakiyingi, J Watera, C Brown, M Joseph, S French, N Gilks, C Whitworth, J Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. |
| title | Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. |
| title_full | Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. |
| title_fullStr | Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. |
| title_full_unstemmed | Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. |
| title_short | Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans. |
| title_sort | eosinophilia and progression to active tuberculosis in hiv 1 infected ugandans |
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