Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Calreticulin (CALR) frameshift mutations represent the second cause of myeloproliferative neoplasms (MPN). In healthy cells, CALR transiently and non-specifically interacts with immature N-glycosylated proteins through its N-terminal domain. Conversely, CALR frameshift mutants turn into rogue cytoki...

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Dettagli Bibliografici
Autori principali:	Papadopoulos, N, Nédélec, A, Derenne, A, Şulea, TA, Pecquet, C, Chachoua, I, Vertenoeil, G, Tilmant, T, Petrescu, A-J, Mazzucchelli, G, Iorga, BI, Vertommen, D, Constantinescu, SN
Natura:	Journal article
Lingua:	English
Pubblicazione:	Springer Nature 2023
Soggetti:	Structural biology Myeloproliferative disease

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