Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation

Calreticulin (CALR) frameshift mutations represent the second cause of myeloproliferative neoplasms (MPN). In healthy cells, CALR transiently and non-specifically interacts with immature N-glycosylated proteins through its N-terminal domain. Conversely, CALR frameshift mutants turn into rogue cytoki...

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Những tác giả chính: Papadopoulos, N, Nédélec, A, Derenne, A, Şulea, TA, Pecquet, C, Chachoua, I, Vertenoeil, G, Tilmant, T, Petrescu, A-J, Mazzucchelli, G, Iorga, BI, Vertommen, D, Constantinescu, SN
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Springer Nature 2023
Những chủ đề:
Structural biology
Myeloproliferative disease

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