Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1).
The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and recombination studies, and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course of constructing a conting, we have identified the location of t...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1797093258662248448 |
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| author | Forbes, SA Pannett, A Bassett, J Harding, B Wooding, C Thakker, R Butler, R Ogilvie, D Anand, R Gaudray, P Weber, G Larsson, C Zhang, C Calender, A Höppener, J Lips, C Kas, K |
| author_facet | Forbes, SA Pannett, A Bassett, J Harding, B Wooding, C Thakker, R Butler, R Ogilvie, D Anand, R Gaudray, P Weber, G Larsson, C Zhang, C Calender, A Höppener, J Lips, C Kas, K |
| author_sort | Forbes, SA |
| collection | OXFORD |
| description | The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and recombination studies, and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course of constructing a conting, we have identified the location of the gene encoding the B56 beta subunit of protein phosphatase 2A (PP2A), which is involved in cell signal transduction pathways and thus represents a candidate gene for MEN1. We have searched for mutations in the PP2A-B56 beta coding region, together with the 5' and 3' untranslated regions in six MEN1 patients. DNA sequence abnormalities were not identified and thus the PP2A-B56 beta gene is excluded as the candidate gene for MEN1. However, our precise localisation of PP2A-B56 beta to this region of 11q13 may help in elucidating the basis for other disease genes mapping to this generich region. |
| first_indexed | 2024-03-07T03:57:43Z |
| format | Journal article |
| id | oxford-uuid:c372d3e8-bae4-43c5-ad28-dae62d4c5695 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:57:43Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:c372d3e8-bae4-43c5-ad28-dae62d4c56952022-03-27T06:16:33ZMapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c372d3e8-bae4-43c5-ad28-dae62d4c5695EnglishSymplectic Elements at Oxford1997Forbes, SAPannett, ABassett, JHarding, BWooding, CThakker, RButler, ROgilvie, DAnand, RGaudray, PWeber, GLarsson, CZhang, CCalender, AHöppener, JLips, CKas, KThe multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and recombination studies, and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course of constructing a conting, we have identified the location of the gene encoding the B56 beta subunit of protein phosphatase 2A (PP2A), which is involved in cell signal transduction pathways and thus represents a candidate gene for MEN1. We have searched for mutations in the PP2A-B56 beta coding region, together with the 5' and 3' untranslated regions in six MEN1 patients. DNA sequence abnormalities were not identified and thus the PP2A-B56 beta gene is excluded as the candidate gene for MEN1. However, our precise localisation of PP2A-B56 beta to this region of 11q13 may help in elucidating the basis for other disease genes mapping to this generich region. |
| spellingShingle | Forbes, SA Pannett, A Bassett, J Harding, B Wooding, C Thakker, R Butler, R Ogilvie, D Anand, R Gaudray, P Weber, G Larsson, C Zhang, C Calender, A Höppener, J Lips, C Kas, K Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |
| title | Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |
| title_full | Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |
| title_fullStr | Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |
| title_full_unstemmed | Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |
| title_short | Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). |
| title_sort | mapping of the gene encoding the b56 beta subunit of protein phosphatase 2a ppp2r5b to a 0 5 mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 men1 |
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