Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention?
The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinic...
| Main Authors: | , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
2012
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| _version_ | 1826295225028444160 |
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| author | Williams, H Fisher, E Greaves, D |
| author_facet | Williams, H Fisher, E Greaves, D |
| author_sort | Williams, H |
| collection | OXFORD |
| description | The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage numbers and macrophage differentiation within the atherosclerotic plaque microenvironment and discuss potential approaches to target macrophage differentiation for therapeutic benefit in cardiovascular disease. |
| first_indexed | 2024-03-07T03:57:45Z |
| format | Journal article |
| id | oxford-uuid:c375dc2c-76e4-42af-bcfa-cb1512c5f04c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:57:45Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:c375dc2c-76e4-42af-bcfa-cb1512c5f04c2022-03-27T06:16:30ZMacrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c375dc2c-76e4-42af-bcfa-cb1512c5f04cEnglishSymplectic Elements at Oxford2012Williams, HFisher, EGreaves, DThe macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage numbers and macrophage differentiation within the atherosclerotic plaque microenvironment and discuss potential approaches to target macrophage differentiation for therapeutic benefit in cardiovascular disease. |
| spellingShingle | Williams, H Fisher, E Greaves, D Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? |
| title | Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? |
| title_full | Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? |
| title_fullStr | Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? |
| title_full_unstemmed | Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? |
| title_short | Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? |
| title_sort | macrophage differentiation and function in atherosclerosis opportunities for therapeutic intervention |
| work_keys_str_mv | AT williamsh macrophagedifferentiationandfunctioninatherosclerosisopportunitiesfortherapeuticintervention AT fishere macrophagedifferentiationandfunctioninatherosclerosisopportunitiesfortherapeuticintervention AT greavesd macrophagedifferentiationandfunctioninatherosclerosisopportunitiesfortherapeuticintervention |