Intracranial pressure in childhood cerebral malaria.
Lumbar punctures were performed in 40 Gambian children with acute cerebral malaria aged between 18 months and 10 years. The mean opening pressure was elevated in 32 (80%) of the children, but was not significantly different in the 14 fatal cases compared with survivors: 110 (standard deviation 71) v...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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| _version_ | 1826295235653664768 |
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| author | Waller, D Crawley, J Nosten, F Chapman, D Krishna, S Craddock, C Brewster, D White, N |
| author_facet | Waller, D Crawley, J Nosten, F Chapman, D Krishna, S Craddock, C Brewster, D White, N |
| author_sort | Waller, D |
| collection | OXFORD |
| description | Lumbar punctures were performed in 40 Gambian children with acute cerebral malaria aged between 18 months and 10 years. The mean opening pressure was elevated in 32 (80%) of the children, but was not significantly different in the 14 fatal cases compared with survivors: 110 (standard deviation 71) versus 131 (58) mm of cerebrospinal fluid respectively. Cerebral perfusion pressures were also similar in the 2 groups: 64 (20) mm Hg versus 64 (11) mm Hg respectively. There was no clear clinical evidence of raised intracranial pressure, and no evidence of deterioration immediately following lumbar puncture. Nevertheless brain swelling, and consequent brain-stem compression, may contribute to a fatal outcome in cerebral malaria--particularly in those children who die from sudden respiratory arrest. A prospective evaluation of osmotic agents in childhood cerebral malaria seems to be justified. |
| first_indexed | 2024-03-07T03:57:55Z |
| format | Journal article |
| id | oxford-uuid:c3800442-8b89-4fac-82c4-079a7c79ce71 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:57:55Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:c3800442-8b89-4fac-82c4-079a7c79ce712022-03-27T06:16:56ZIntracranial pressure in childhood cerebral malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c3800442-8b89-4fac-82c4-079a7c79ce71EnglishSymplectic Elements at Oxford1991Waller, DCrawley, JNosten, FChapman, DKrishna, SCraddock, CBrewster, DWhite, NLumbar punctures were performed in 40 Gambian children with acute cerebral malaria aged between 18 months and 10 years. The mean opening pressure was elevated in 32 (80%) of the children, but was not significantly different in the 14 fatal cases compared with survivors: 110 (standard deviation 71) versus 131 (58) mm of cerebrospinal fluid respectively. Cerebral perfusion pressures were also similar in the 2 groups: 64 (20) mm Hg versus 64 (11) mm Hg respectively. There was no clear clinical evidence of raised intracranial pressure, and no evidence of deterioration immediately following lumbar puncture. Nevertheless brain swelling, and consequent brain-stem compression, may contribute to a fatal outcome in cerebral malaria--particularly in those children who die from sudden respiratory arrest. A prospective evaluation of osmotic agents in childhood cerebral malaria seems to be justified. |
| spellingShingle | Waller, D Crawley, J Nosten, F Chapman, D Krishna, S Craddock, C Brewster, D White, N Intracranial pressure in childhood cerebral malaria. |
| title | Intracranial pressure in childhood cerebral malaria. |
| title_full | Intracranial pressure in childhood cerebral malaria. |
| title_fullStr | Intracranial pressure in childhood cerebral malaria. |
| title_full_unstemmed | Intracranial pressure in childhood cerebral malaria. |
| title_short | Intracranial pressure in childhood cerebral malaria. |
| title_sort | intracranial pressure in childhood cerebral malaria |
| work_keys_str_mv | AT wallerd intracranialpressureinchildhoodcerebralmalaria AT crawleyj intracranialpressureinchildhoodcerebralmalaria AT nostenf intracranialpressureinchildhoodcerebralmalaria AT chapmand intracranialpressureinchildhoodcerebralmalaria AT krishnas intracranialpressureinchildhoodcerebralmalaria AT craddockc intracranialpressureinchildhoodcerebralmalaria AT brewsterd intracranialpressureinchildhoodcerebralmalaria AT whiten intracranialpressureinchildhoodcerebralmalaria |