Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype.

Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype.

Apolipoprotein E (ApoE) is a potent risk factor for Alzheimer's disease. Since the loss of cholinergic function in Alzheimer's disease is known to occur at an early stage in the disease we have examined this function in normal subjects with an Apoepsilon4 allele to see if the deficit occur...

Bibliografski detalji
Glavni autori:	Allen, S, MacGowan, S, Tyler, S, Wilcock, G, Robertson, A, Holden, P, Smith, S, Dawbarn, D
Format:	Journal article
Jezik:	English
Izdano:	1997

Slični predmeti

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od: MacGowan, S, i dr.
Izdano: (1998)

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od: Allen, S, i dr.
Izdano: (1990)

Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain.
od: Treanor, J, i dr.
Izdano: (1991)

Normal beta-NGF content in Alzheimer's disease cerebral cortex and hippocampus.
od: Allen, S, i dr.
Izdano: (1991)

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od: Lin, W, i dr.
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od: Treanor, J, i dr.
Izdano: (1990)

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od: Lin, W, i dr.
Izdano: (1998)

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od: Ahmed, A, i dr.
Izdano: (1999)

DISTRIBUTION OF NGF RECEPTORS IN CONTROL AND ALZHEIMERS-DISEASE BASAL FOREBRAIN
od: Dawbarn, D, i dr.
Izdano: (1990)

Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.
od: Allen, S, i dr.
Izdano: (1994)

Changes in alpha- and beta-secretase in Alzheimer's disease
od: Tyler, S, i dr.
Izdano: (2003)

alpha- and beta-secretase: profound changes in Alzheimer's disease.
od: Tyler, S, i dr.
Izdano: (2002)

Treatment of the cholinergic impairment in Alzheimer's disease
od: Wilcock, G
Izdano: (1994)

Apolipoprotein E genotyping in Alzheimer's disease. The UK Alzheimer's Disease Genetic consortium.
od: Lovestone, S, i dr.
Izdano: (1996)

Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease.
od: Goedert, M, i dr.
Izdano: (1989)

Morphometric immunochemical analysis of neurons in the nucleus basalis of Meynert in Alzheimer's disease.
od: Allen, S, i dr.
Izdano: (1988)

Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.
od: Allen, S, i dr.
Izdano: (1999)

HLA-DR3 and DQA1*0401: possible risk factors in Alzheimer's disease
od: Culpan, D, i dr.
Izdano: (1999)

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od: Culpan, D, i dr.
Izdano: (2002)

Recombinant human nerve growth factor for clinical trials: protein expression, purification, stability and characterisation of binding to infusion pumps.
od: Allen, S, i dr.
Izdano: (2001)

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od: Wilcock, G, i dr.
Izdano: (1994)

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od: Charles Ramassamy, i dr.
Izdano: (2000-02-01)

The cholinergic hypothesis of Alzheimer's disease: a review of progress.
od: Francis, P, i dr.
Izdano: (1999)

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od: Irundika HK Dias, i dr.
Izdano: (2022-01-01)

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od: Francis, P, i dr.
Izdano: (1999)

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od: Uwe Beffert, i dr.
Izdano: (2020-12-01)

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od: Bowen, D, i dr.
Izdano: (1983)

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
od: Holden, P, i dr.
Izdano: (1997)

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od: P. Huebbe, i dr.
Izdano: (2012-11-01)

Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase.
od: Pearson, R, i dr.
Izdano: (1983)

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od: Caroline Petit-Turcotte, i dr.
Izdano: (2001-12-01)

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od: Roni Bar, i dr.
Izdano: (2018-01-01)

Brain tissue banks in psychiatric and neurological research.
od: Wilcock, G, i dr.
Izdano: (1997)

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od: Zhi-Ru Chen, i dr.
Izdano: (2022-03-01)

Alzheimer′s disease, anesthesia and the cholinergic system
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Izdano: (2011-01-01)

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Izdano: (2021-10-01)

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Izdano: (2018-01-01)

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Izdano: (2015-09-01)

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od: Jamieson, G, i dr.
Izdano: (1991)