The cytotoxic action of lymphokine activated killer cells upon the human glioma cell line U251 is stimulated by bispecific monoclonal antibody (MoAb) constructs.

The ability of IL-2 stimulated mononuclear cells to kill the human glioblastoma cell line U251 has been investigated. Highest cytotoxic activity was generated in low cell density cultures incubated for 15 days with 250-1000 U/ml IL-2. Sub-optimal killing was noted, with cells only exposed to IL-2 fo...

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Bibliographic Details
Main Authors: Obukhov, S, Gennie, M, Tutt, A, Kemshead, J, Coakham, H, Beverely, P
Format: Journal article
Language:English
Published: 1992