Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.
Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential the...
| Հիմնական հեղինակներ: | , , , , |
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| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
2011
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| _version_ | 1826295297047789568 |
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| author | Veerapen, N Reddington, F Salio, M Cerundolo, V Besra, G |
| author_facet | Veerapen, N Reddington, F Salio, M Cerundolo, V Besra, G |
| author_sort | Veerapen, N |
| collection | OXFORD |
| description | Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with truncated sphingosine chains for biological evaluation, with particular emphasis on the Th1/Th2 distribution. Starting from a common precursor, d-lyxose, the sphingosine derivatives were synthesised via a straightforward Wittig condensation. |
| first_indexed | 2024-03-07T03:58:51Z |
| format | Journal article |
| id | oxford-uuid:c3cfe35d-d305-4839-8870-7f8db4132651 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:58:51Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:c3cfe35d-d305-4839-8870-7f8db41326512022-03-27T06:19:09ZSynthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c3cfe35d-d305-4839-8870-7f8db4132651EnglishSymplectic Elements at Oxford2011Veerapen, NReddington, FSalio, MCerundolo, VBesra, GStimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. Skewing of the iNKT cells' response towards either a Th1- or Th2-cytokine profile offers potential therapeutic benefits. The length of both the acyl and the sphingosine chains in α-galactosyl ceramides is known to influence the cytokine release profile. We have synthesized analogues of α-GalCer with truncated sphingosine chains for biological evaluation, with particular emphasis on the Th1/Th2 distribution. Starting from a common precursor, d-lyxose, the sphingosine derivatives were synthesised via a straightforward Wittig condensation. |
| spellingShingle | Veerapen, N Reddington, F Salio, M Cerundolo, V Besra, G Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. |
| title | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. |
| title_full | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. |
| title_fullStr | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. |
| title_full_unstemmed | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. |
| title_short | Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. |
| title_sort | synthesis of truncated analogues of the inkt cell agonist α galactosyl ceramide krn7000 and their biological evaluation |
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