Calorimetric dissection of colicin DNase--immunity protein complex specificity.

We explore the thermodynamic strategies used to achieve specific, high-affinity binding within a family of conserved protein-protein complexes. Protein-protein interactions are often stabilized by a conserved interfacial hotspot that serves as the anchor for the complex, with neighboring variable re...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Keeble, A, Kirkpatrick, N, Shimizu, S, Kleanthous, K
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: 2006