Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.
The oxygen sensitive prolyl-hydroxylase domain enzymes (PHDs) and the asparagines hydroxylase (FIH, factor inhibiting HIF) regulate the transcriptional activity of HIFs. We assessed the expression of these enzymes in a series of 73 non-small cell lung carcinomas (NSCLC). A direct association of PHDs...
Автори: | Giatromanolaki, A, Koukourakis, M, Pezzella, F, Turley, H, Sivridis, E, Bouros, D, Bougioukas, G, Harris, A, Gatter, K |
---|---|
Формат: | Journal article |
Мова: | English |
Опубліковано: |
2008
|
Схожі ресурси
Схожі ресурси
-
Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
за авторством: Giatromanolaki, A, та інші
Опубліковано: (2008) -
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
за авторством: McNeill, L, та інші
Опубліковано: (2002) -
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
за авторством: Hewitson, K, та інші
Опубліковано: (2002) -
Regulation of HIF: prolyl hydroxylases.
за авторством: Stolze, I, та інші
Опубліковано: (2006) -
Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival.
за авторством: Sigve Andersen, та інші
Опубліковано: (2011-01-01)