Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes

Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes

We compared commonly used BAPTA-derived chemical Ca<sup>2+</sup> dyes (fura2, Fluo-4, and Rhod-2) with a newer genetically encoded indicator (R-GECO) in single cell models of the heart. We assessed their performance and effects on cardiomyocyte contractility, determining fluorescent sign...

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Bibliographic Details
Main Authors: Robinson, P, Sparrow, AJ, Psaras, Y, Steeples, V, Simon, JN, Broyles, CN, Chang, Y-F, Brook, FA, Wang, Y-J, Blease, A, Zhang, X, Abassi, YA, Geeves, MA, Toepfer, CN, Watkins, H, Redwood, C, Daniels, MJ
Format: Journal article
Language:English
Published: Elsevier 2023

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