Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

Geahča maid

• Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
  Dahkki: Horsch, K, et al.
  Almmustuhtton: (2004)
• Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents
  Dahkki: Hulley, P, et al.
  Almmustuhtton: (2003)
• Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.
  Dahkki: Horsch, K, et al.
  Almmustuhtton: (2007)
• Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
  Dahkki: Hulley, P, et al.
  Almmustuhtton: (2002)
• Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
  Dahkki: Engelbrecht, Y, et al.
  Almmustuhtton: (2003)