Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

Show other versions (1)

Bibliographic Details
Main Authors:	Horsch, K, De Wet, H, Langeveldt, C, Hough, S, Burrin, J, Cunningham, J, Schuurmans, M, Hulley, P
Format:	Conference item
Published:	2004

Similar Items

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
by: Horsch, K, et al.
Published: (2004)

Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents
by: Hulley, P, et al.
Published: (2003)

Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.
by: Horsch, K, et al.
Published: (2007)

Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
by: Engelbrecht, Y, et al.
Published: (2003)

Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
by: Hulley, P, et al.
Published: (2002)

Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.
by: Conradie, M, et al.
Published: (2007)

MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.
by: Conradie, M, et al.
Published: (2011)

The Role of MKP-1 in the Anti-Proliferative Effects of Glucocorticoids in Primary Rat Pre-Osteoblasts.
by: Micheline Sanderson, et al.
Published: (2015-01-01)

Alternative insulin signalling pathways in osteoblasts
by: Langeveldt, C, et al.
Published: (2002)

Alternative insulin signalling pathways in osteoblast cell lines
by: Langeveldt, C, et al.
Published: (2002)

Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
by: Hulley, P, et al.
Published: (2002)

The tyrosine phosphatase inhibitor vanadate protects osteoblasts from growth inhibition by glucocorticoids.
by: Hulley, P, et al.
Published: (1999)

Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast
by: Chien-Ning Hsu, et al.
Published: (2020-01-01)

Corrigendum: Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast
Published: (2021-01-01)

Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.
by: Espina, B, et al.
Published: (2008)

BIM is a novel regulator of glucocorticoid-induced apoptosis in osteoblasts
by: Espina, B, et al.
Published: (2006)

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
by: Zhongyi Shen, et al.
Published: (2019-03-01)

Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding
by: Jacob Sellers, et al.
Published: (2021-11-01)

Inhibition of mitogen-activated protein kinase activity and proliferation of an early osteoblast cell line (MBA 15.4) by dexamethasone: role of protein phosphatases.
by: Hulley, P, et al.
Published: (1998)

MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
by: Jaya Talreja, et al.
Published: (2024-01-01)

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis
by: Ok-Seon Kwon, et al.
Published: (2020-04-01)

Protection against glucocorticoid-induced damage in human tenocytes by modulation of ERK, Akt, and forkhead signaling.
by: Poulsen, R, et al.
Published: (2011)

Regulation of the CCL2 gene in pancreatic β-cells by IL-1β and glucocorticoids: role of MKP-1.
by: Susan J Burke, et al.
Published: (2012-01-01)

Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation.
by: Yu-xian Yan, et al.
Published: (2012-01-01)

Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease
by: Savanie Fernando, et al.
Published: (2022-06-01)

Cynarin attenuates LPS-induced endothelial inflammation via upregulation of the negative regulator MKP-3
by: Da Bin Kim, et al.
Published: (2022-05-01)

Identification of polymorphisms in the MKP1 gene and their association with bone mineral density in men with asthma
by: Bassiti, A, et al.
Published: (2005)

Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing.
by: Cristina Molnar, et al.
Published: (2013-01-01)

Ischemia/reperfusion-induced MKP-3 impairs endothelial NO formation via inactivation of ERK1/2 pathway.
by: Dan Yang, et al.
Published: (2012-01-01)

Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation
by: Seung-Woo Kim, et al.
Published: (2024-12-01)

Pathogenesis of glucocorticoid osteoporosis: Role of tyrosine phosphatases
by: Hulley, P, et al.
Published: (2001)

The BH3-only protein BIM is upregulated in osteoblasts in response to dexamethasone treatment, growth factor deprivation and anoikis
by: Espina, B, et al.
Published: (2005)

Role and regulation of MKP-1 in airway inflammation
by: Seyed M. Moosavi, et al.
Published: (2017-08-01)

MECHANISMS OF OSTEOBLAST INHIBITION BY STEROIDS
by: Hulley, P
Published: (2004)

Randomness improvement of AES using MKP
by: Al-Alak, Saif, et al.
Published: (2013)

Nonlinearity contributions on critical MKP equation
by: H.G. Abdelwahed
Published: (2020-01-01)

Osteoblast-osteoclast co-culture amplifies inhibitory effects of FG-4592 on human osteoclastogenesis and reduces bone resorption
by: Hulley, P, et al.
Published: (2020)

N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling.
by: Eric Haÿ, et al.
Published: (2009-01-01)

Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes
by: Manuel Gado, et al.
Published: (2022-03-01)

CYLD negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK.
by: Wenzhuo Y Wang, et al.
Published: (2014-01-01)