Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1

عرض إصدارات أخرى (1)

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Horsch, K, De Wet, H, Langeveldt, C, Hough, S, Burrin, J, Cunningham, J, Schuurmans, M, Hulley, P
التنسيق:	Conference item
منشور في:	2004

مواد مشابهة

Rapid inhibitory effects of glucocorticoids on ERK activity and osteoblast proliferation occur via transcriptional upregulation of MKP-1
حسب: Horsch, K, وآخرون
منشور في: (2004)

Glucocorticoids inhibit osteoblast proliferation via transcriptional upregulation of MKP-1: A prime target for the development of novel osteo-anabolic agents
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Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation.
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Vanadate protects osteoblasts in vitro and in vivo from glucocorticoid impairment of proliferation
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Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines.
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Vanadate prevents glucocorticoid-induced apoptosis of osteoblasts in vitro and osteocytes in vivo.
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MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice.
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Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
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The tyrosine phosphatase inhibitor vanadate protects osteoblasts from growth inhibition by glucocorticoids.
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Regulation of bim in glucocorticoid-mediated osteoblast apoptosis.
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The BH3-only protein BIM is upregulated in osteoblasts in response to dexamethasone treatment, growth factor deprivation and anoikis
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N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling.
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MECHANISMS OF OSTEOBLAST INHIBITION BY STEROIDS
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Osteoblast-osteoclast co-culture amplifies inhibitory effects of FG-4592 on human osteoclastogenesis and reduces bone resorption
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Prenatal dexamethasone exposure reduces osteoprogenitor proliferation in mice via histone modifications at the Mkp-1 gene locus
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Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1
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SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
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