An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW).
OBJECTIVES: Patients with osteoarthritis have increased bone mass but no decrease in fractures. The association between self-reported osteoarthritis and incident falls and fractures was studied in postmenopausal women. METHODS: The Global Longitudinal Study of Osteoporosis in Women is a prospective...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1797093421828014080 |
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| author | Prieto-Alhambra, D Nogues, X Javaid, M Wyman, A Arden, N Azagra, R Cooper, C Adachi, J Boonen, S Chapurlat, R Compston, J Gehlbach, S Greenspan, S Hooven, F Netelenbos, J Pfeilschifter, J Rossini, M Sambrook, P Silverman, S Siris, E Watts, N Díez-Pérez, A |
| author_facet | Prieto-Alhambra, D Nogues, X Javaid, M Wyman, A Arden, N Azagra, R Cooper, C Adachi, J Boonen, S Chapurlat, R Compston, J Gehlbach, S Greenspan, S Hooven, F Netelenbos, J Pfeilschifter, J Rossini, M Sambrook, P Silverman, S Siris, E Watts, N Díez-Pérez, A |
| author_sort | Prieto-Alhambra, D |
| collection | OXFORD |
| description | OBJECTIVES: Patients with osteoarthritis have increased bone mass but no decrease in fractures. The association between self-reported osteoarthritis and incident falls and fractures was studied in postmenopausal women. METHODS: The Global Longitudinal Study of Osteoporosis in Women is a prospective multinational cohort of 60,393 non-institutionalised women aged ≥55 years who had visited primary care practices within the previous 2 years. Questionnaires were mailed at yearly intervals. Patients were classified as having osteoarthritis if they answered yes to the question, 'Has a doctor or other health provider ever said that you had osteoarthritis or degenerative joint disease?', and this was validated against primary care records in a subsample. Information on incident falls, fractures and covariates was self-reported. Cox and Poisson models were used for incident fractures and number of falls, respectively, to compute hazard ratios (HRs) and rate ratios (RRs) for baseline osteoarthritis status. RESULTS: Of 51 386 women followed for a median of 2.9 years (interquartile range 2.1-3.0), 20 409 (40%) reported osteoarthritis. The adjusted HR for osteoarthritis predicting fracture was 1.21 (95% CI 1.13 to 1.30; p<0.0001) and the adjusted RR for falls was 1.24 (95% CI 1.22 to 1.26; p<0.0001). However, the association between osteoarthritis and fracture was not significant after adjustment for incident falls (HR 1.06 (95% CI 0.98 to 1.15; p=0.13)). CONCLUSIONS: Postmenopausal women with self-reported osteoarthritis have a 20% increased risk of fracture and experience 25% more falls than those without osteoarthritis. These data suggest that increased falls are the causal pathway of the association between osteoarthritis and fractures. |
| first_indexed | 2024-03-07T04:00:08Z |
| format | Journal article |
| id | oxford-uuid:c44603f0-2f93-403b-a541-3234349d7756 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:00:08Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:c44603f0-2f93-403b-a541-3234349d77562022-03-27T06:22:21ZAn increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c44603f0-2f93-403b-a541-3234349d7756EnglishSymplectic Elements at Oxford2013Prieto-Alhambra, DNogues, XJavaid, MWyman, AArden, NAzagra, RCooper, CAdachi, JBoonen, SChapurlat, RCompston, JGehlbach, SGreenspan, SHooven, FNetelenbos, JPfeilschifter, JRossini, MSambrook, PSilverman, SSiris, EWatts, NDíez-Pérez, AOBJECTIVES: Patients with osteoarthritis have increased bone mass but no decrease in fractures. The association between self-reported osteoarthritis and incident falls and fractures was studied in postmenopausal women. METHODS: The Global Longitudinal Study of Osteoporosis in Women is a prospective multinational cohort of 60,393 non-institutionalised women aged ≥55 years who had visited primary care practices within the previous 2 years. Questionnaires were mailed at yearly intervals. Patients were classified as having osteoarthritis if they answered yes to the question, 'Has a doctor or other health provider ever said that you had osteoarthritis or degenerative joint disease?', and this was validated against primary care records in a subsample. Information on incident falls, fractures and covariates was self-reported. Cox and Poisson models were used for incident fractures and number of falls, respectively, to compute hazard ratios (HRs) and rate ratios (RRs) for baseline osteoarthritis status. RESULTS: Of 51 386 women followed for a median of 2.9 years (interquartile range 2.1-3.0), 20 409 (40%) reported osteoarthritis. The adjusted HR for osteoarthritis predicting fracture was 1.21 (95% CI 1.13 to 1.30; p<0.0001) and the adjusted RR for falls was 1.24 (95% CI 1.22 to 1.26; p<0.0001). However, the association between osteoarthritis and fracture was not significant after adjustment for incident falls (HR 1.06 (95% CI 0.98 to 1.15; p=0.13)). CONCLUSIONS: Postmenopausal women with self-reported osteoarthritis have a 20% increased risk of fracture and experience 25% more falls than those without osteoarthritis. These data suggest that increased falls are the causal pathway of the association between osteoarthritis and fractures. |
| spellingShingle | Prieto-Alhambra, D Nogues, X Javaid, M Wyman, A Arden, N Azagra, R Cooper, C Adachi, J Boonen, S Chapurlat, R Compston, J Gehlbach, S Greenspan, S Hooven, F Netelenbos, J Pfeilschifter, J Rossini, M Sambrook, P Silverman, S Siris, E Watts, N Díez-Pérez, A An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). |
| title | An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). |
| title_full | An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). |
| title_fullStr | An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). |
| title_full_unstemmed | An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). |
| title_short | An increased rate of falling leads to a rise in fracture risk in postmenopausal women with self-reported osteoarthritis: a prospective multinational cohort study (GLOW). |
| title_sort | increased rate of falling leads to a rise in fracture risk in postmenopausal women with self reported osteoarthritis a prospective multinational cohort study glow |
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