Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits
Breast cancer and prostate cancer are the most common cancers diagnosed in women and men, respectively, in the UK, and radiotherapy is used extensively in the treatment of both. In vitro data suggest that tumours in the breast and prostate have unique properties that make a hypofractionated radiothe...
| Asıl Yazarlar: | , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Elsevier
2015
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| _version_ | 1826311770347667456 |
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| author | Ray, KJ Sibson, NR Kiltie, AE |
| author_facet | Ray, KJ Sibson, NR Kiltie, AE |
| author_sort | Ray, KJ |
| collection | OXFORD |
| description | Breast cancer and prostate cancer are the most common cancers diagnosed in women and men, respectively, in the UK, and radiotherapy is used extensively in the treatment of both. In vitro data suggest that tumours in the breast and prostate have unique properties that make a hypofractionated radiotherapy treatment schedule advantageous in terms of therapeutic index. Many clinical trials of hypofractionated radiotherapy treatment schedules have been completed to establish the extent to which hypofractionation can improve patient outcome. Here we present a concise description of hypofractionation, the mathematical description of converting between conventional and hypofractionated schedules, and the motivation for using hypofractionation in the treatment of breast and prostate cancer. Furthermore, we summarise the results of important recent hypofractionation trials and highlight the limitations of a hypofractionated treatment regimen. |
| first_indexed | 2024-03-07T08:16:10Z |
| format | Journal article |
| id | oxford-uuid:c46f546c-b62f-4369-8ce0-1f89213f6a7c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:16:10Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:c46f546c-b62f-4369-8ce0-1f89213f6a7c2024-01-03T10:38:38ZTreatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefitsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c46f546c-b62f-4369-8ce0-1f89213f6a7cEnglishSymplectic Elements at OxfordElsevier2015Ray, KJSibson, NRKiltie, AEBreast cancer and prostate cancer are the most common cancers diagnosed in women and men, respectively, in the UK, and radiotherapy is used extensively in the treatment of both. In vitro data suggest that tumours in the breast and prostate have unique properties that make a hypofractionated radiotherapy treatment schedule advantageous in terms of therapeutic index. Many clinical trials of hypofractionated radiotherapy treatment schedules have been completed to establish the extent to which hypofractionation can improve patient outcome. Here we present a concise description of hypofractionation, the mathematical description of converting between conventional and hypofractionated schedules, and the motivation for using hypofractionation in the treatment of breast and prostate cancer. Furthermore, we summarise the results of important recent hypofractionation trials and highlight the limitations of a hypofractionated treatment regimen. |
| spellingShingle | Ray, KJ Sibson, NR Kiltie, AE Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits |
| title | Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits |
| title_full | Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits |
| title_fullStr | Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits |
| title_full_unstemmed | Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits |
| title_short | Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits |
| title_sort | treatment of breast and prostate cancer by hypofractionated radiotherapy potential risks and benefits |
| work_keys_str_mv | AT raykj treatmentofbreastandprostatecancerbyhypofractionatedradiotherapypotentialrisksandbenefits AT sibsonnr treatmentofbreastandprostatecancerbyhypofractionatedradiotherapypotentialrisksandbenefits AT kiltieae treatmentofbreastandprostatecancerbyhypofractionatedradiotherapypotentialrisksandbenefits |