Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.

Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.

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Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM glycosaminoglycans or is endocytosed by cells via low-density lipoprotein receptor-related protein 1 (LRP-1). Here, we report that heparan sulfate (HS) and...

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Bibliographic Details
Main Authors:	Troeberg, L, Lazenbatt, C, Anower-E-Khuda, M, Freeman, C, Federov, O, Habuchi, H, Habuchi, O, Kimata, K, Nagase, H
Format:	Journal article
Language:	English
Published:	2014

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