SYNTHESIS OF 1,5-DIDEOXY-3-O-(ALPHA-D-MANNOPYRANOSYL)-1,5-IMINO-D-MANNITOL AND 1,5-DIDEOXY-3-O-(ALPHA-D-GLUCOPYRANOSYL)-1,5-IMINO-D-MANNITOL - POWERFUL INHIBITORS OF ENDOMANNOSIDASE
The synthesis and conformations of 3-O-methylDMJ, 3-O-(α-D-glucopyranosyl)-DMJ (Glcα1,3DMJ), and 3-O-(α-D-mannopyranosyl)-DMJ (Manα1,3DMJ) are described. Manα1,3DMJ and Glcα1,3DMJ are shown to be very powerful inhibitors of an endomannosidase. The potential use of these compounds in both probing the...
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Bibliographic Details
Main Authors: |
Ardron, H,
Butters, T,
Platt, F,
Wormald, M,
Dwek, R,
Fleet, G,
Jacob, G |
Format: | Journal article
|
Language: | English |
Published: |
1993
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