A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease
<p><strong>Background</strong> An unmet need remains for sensitive outcome measures in neuroprotective trials. The study aims to determine whether a composite clinical motor score, combining the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III mot...
| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
BMJ Publishing Group
2022
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| _version_ | 1826317553136304128 |
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| author | Lo, C Arora, S Lawton, M Barber, T Quinnell, T Dennis, GJ Ben-Shlomo, Y Hu, MT-M |
| author_facet | Lo, C Arora, S Lawton, M Barber, T Quinnell, T Dennis, GJ Ben-Shlomo, Y Hu, MT-M |
| author_sort | Lo, C |
| collection | OXFORD |
| description | <p><strong>Background</strong> An unmet need remains for sensitive outcome measures in neuroprotective trials. The study aims to determine whether a composite clinical motor score, combining the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III motor examination score, Purdue Pegboard Test, and Timed Up and Go, provides greater sensitivity in detecting motor change in early disease than the MDS-UPDRS III alone.</p>
<p><strong>Methods</strong> The Oxford Discovery longitudinal cohort study involves individuals with isolated rapid eye movement sleep behaviour disorder (iRBD) (n=272, confirmed polysomnographically, median follow-up: 1.6 years), idiopathic Parkinson’s disease (PD) (n=909, median follow-up: 3.5 years, baseline: <3.5 years disease duration) and controls (n=316, age-matched and sex-matched, without a first-degree family history of PD). Motor and non-motor assessments were performed at each in-person visit.</p>
<p><strong>Results</strong> Compared with the MDS-UPDRS III, the composite clinical motor score demonstrated a wider score distribution in iRBD and controls, lower coefficient of variation (37% vs 67%), and higher correlation coefficients with self-reported measures of motor severity (0.65 vs 0.61) and overall health status (−0.40 vs −0.33). Greater score range in mild to moderate PD, higher magnitude of longitudinal change in iRBD and longitudinal score linearity suggest better sensitivity in detecting subtle motor change. The composite clinical motor score was more accurate than the MDS-UPDRS III in predicting clinical outcomes, requiring 64% fewer participants with PD and 51% fewer participants with iRBD in sample size estimations for a hypothetical 18-month placebo-controlled clinical trial.</p>
<p><strong>Conclusion</strong> The composite clinical motor score may offer greater consistency and sensitivity in detecting change than the MDS-UPDRS III.</p> |
| first_indexed | 2025-03-11T16:55:44Z |
| format | Journal article |
| id | oxford-uuid:c48b799f-2b94-44d2-afdb-24df3ae8f6b2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-03-11T16:55:44Z |
| publishDate | 2022 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:c48b799f-2b94-44d2-afdb-24df3ae8f6b22025-02-20T12:41:37ZA composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's diseaseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c48b799f-2b94-44d2-afdb-24df3ae8f6b2EnglishSymplectic ElementsBMJ Publishing Group2022Lo, CArora, SLawton, MBarber, TQuinnell, TDennis, GJBen-Shlomo, YHu, MT-M<p><strong>Background</strong> An unmet need remains for sensitive outcome measures in neuroprotective trials. The study aims to determine whether a composite clinical motor score, combining the Movement Disorders Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III motor examination score, Purdue Pegboard Test, and Timed Up and Go, provides greater sensitivity in detecting motor change in early disease than the MDS-UPDRS III alone.</p> <p><strong>Methods</strong> The Oxford Discovery longitudinal cohort study involves individuals with isolated rapid eye movement sleep behaviour disorder (iRBD) (n=272, confirmed polysomnographically, median follow-up: 1.6 years), idiopathic Parkinson’s disease (PD) (n=909, median follow-up: 3.5 years, baseline: <3.5 years disease duration) and controls (n=316, age-matched and sex-matched, without a first-degree family history of PD). Motor and non-motor assessments were performed at each in-person visit.</p> <p><strong>Results</strong> Compared with the MDS-UPDRS III, the composite clinical motor score demonstrated a wider score distribution in iRBD and controls, lower coefficient of variation (37% vs 67%), and higher correlation coefficients with self-reported measures of motor severity (0.65 vs 0.61) and overall health status (−0.40 vs −0.33). Greater score range in mild to moderate PD, higher magnitude of longitudinal change in iRBD and longitudinal score linearity suggest better sensitivity in detecting subtle motor change. The composite clinical motor score was more accurate than the MDS-UPDRS III in predicting clinical outcomes, requiring 64% fewer participants with PD and 51% fewer participants with iRBD in sample size estimations for a hypothetical 18-month placebo-controlled clinical trial.</p> <p><strong>Conclusion</strong> The composite clinical motor score may offer greater consistency and sensitivity in detecting change than the MDS-UPDRS III.</p> |
| spellingShingle | Lo, C Arora, S Lawton, M Barber, T Quinnell, T Dennis, GJ Ben-Shlomo, Y Hu, MT-M A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease |
| title | A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease |
| title_full | A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease |
| title_fullStr | A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease |
| title_full_unstemmed | A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease |
| title_short | A composite clinical motor score as a comprehensive and sensitive outcome measure for Parkinson's disease |
| title_sort | composite clinical motor score as a comprehensive and sensitive outcome measure for parkinson s disease |
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