A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift.
A theory of the genetic basis of cerebral asymmetry is outlined according to which (1) a single right-shift factor in all human individuals interacts with (2) epigenetic variation that is apparently random, transmissible between parent and child, but with a half-life extending over a small number of...
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797093473411661824 |
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| author | Crow, T |
| author_facet | Crow, T |
| author_sort | Crow, T |
| collection | OXFORD |
| description | A theory of the genetic basis of cerebral asymmetry is outlined according to which (1) a single right-shift factor in all human individuals interacts with (2) epigenetic variation that is apparently random, transmissible between parent and child, but with a half-life extending over a small number of generations. The right-shift factor arose late (150 to 200 thousand years ago [KYA]) in hominid evolution as a mutation in the X copy of a gene pair (Protocadherin 11XY) in a region of homology between the X and Y chromosomes created by a duplication 6MYA at the chimpanzee hominid separation. The epigenetic imprint originates in the process now known as "meiotic suppression of unpaired chromosomes" (MSUC); it reflects random pairing of partly homologous X and Y chromosome regions in male meiosis, and confers species-specific diversity of cerebral structure on the human population. |
| first_indexed | 2024-03-07T04:00:57Z |
| format | Journal article |
| id | oxford-uuid:c4913c38-7dc7-46fe-ae34-89108aba2f18 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:00:57Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:c4913c38-7dc7-46fe-ae34-89108aba2f182022-03-27T06:24:19ZA theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c4913c38-7dc7-46fe-ae34-89108aba2f18EnglishSymplectic Elements at Oxford2010Crow, TA theory of the genetic basis of cerebral asymmetry is outlined according to which (1) a single right-shift factor in all human individuals interacts with (2) epigenetic variation that is apparently random, transmissible between parent and child, but with a half-life extending over a small number of generations. The right-shift factor arose late (150 to 200 thousand years ago [KYA]) in hominid evolution as a mutation in the X copy of a gene pair (Protocadherin 11XY) in a region of homology between the X and Y chromosomes created by a duplication 6MYA at the chimpanzee hominid separation. The epigenetic imprint originates in the process now known as "meiotic suppression of unpaired chromosomes" (MSUC); it reflects random pairing of partly homologous X and Y chromosome regions in male meiosis, and confers species-specific diversity of cerebral structure on the human population. |
| spellingShingle | Crow, T A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. |
| title | A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. |
| title_full | A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. |
| title_fullStr | A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. |
| title_full_unstemmed | A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. |
| title_short | A theory of the origin of cerebral asymmetry: epigenetic variation superimposed on a fixed right-shift. |
| title_sort | theory of the origin of cerebral asymmetry epigenetic variation superimposed on a fixed right shift |
| work_keys_str_mv | AT crowt atheoryoftheoriginofcerebralasymmetryepigeneticvariationsuperimposedonafixedrightshift AT crowt theoryoftheoriginofcerebralasymmetryepigeneticvariationsuperimposedonafixedrightshift |