Cell sorting by active forces in a phase-field model of cell monolayers
Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in cell sorting. We find that a mixture of cells with extensil...
| Main Authors: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Royal Society of Chemistry
2024
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| _version_ | 1826313110007316480 |
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| author | Graham, JN Zhang, G Yeomans, JM |
| author_facet | Graham, JN Zhang, G Yeomans, JM |
| author_sort | Graham, JN |
| collection | OXFORD |
| description | Cell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in cell sorting. We find that a mixture of cells with extensile or contractile dipolar activity, and which are identical apart from their activity, quickly sort into small, elongated patches which then grow slowly in time. We interpret the sorting as driven by the different diffusivity of the extensile and contractile cells, mirroring the ordering of Brownian particles connected to different hot and cold thermostats. We check that the free energy is not changed by either partial or complete sorting, thus confirming that activity can be responsible for the ordering even in the absence of thermodynamic mechanisms. |
| first_indexed | 2024-09-25T04:05:46Z |
| format | Journal article |
| id | oxford-uuid:c49b516e-aed4-4dc8-88c1-345d82bff42a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:05:46Z |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:c49b516e-aed4-4dc8-88c1-345d82bff42a2024-05-22T11:30:16ZCell sorting by active forces in a phase-field model of cell monolayersJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c49b516e-aed4-4dc8-88c1-345d82bff42aEnglishSymplectic ElementsRoyal Society of Chemistry2024Graham, JNZhang, GYeomans, JMCell sorting, the segregation of cells with different properties into distinct domains, is a key phenomenon in biological processes such as embryogenesis. We use a phase-field model of a confluent cell layer to study the role of activity in cell sorting. We find that a mixture of cells with extensile or contractile dipolar activity, and which are identical apart from their activity, quickly sort into small, elongated patches which then grow slowly in time. We interpret the sorting as driven by the different diffusivity of the extensile and contractile cells, mirroring the ordering of Brownian particles connected to different hot and cold thermostats. We check that the free energy is not changed by either partial or complete sorting, thus confirming that activity can be responsible for the ordering even in the absence of thermodynamic mechanisms. |
| spellingShingle | Graham, JN Zhang, G Yeomans, JM Cell sorting by active forces in a phase-field model of cell monolayers |
| title | Cell sorting by active forces in a phase-field model of cell monolayers |
| title_full | Cell sorting by active forces in a phase-field model of cell monolayers |
| title_fullStr | Cell sorting by active forces in a phase-field model of cell monolayers |
| title_full_unstemmed | Cell sorting by active forces in a phase-field model of cell monolayers |
| title_short | Cell sorting by active forces in a phase-field model of cell monolayers |
| title_sort | cell sorting by active forces in a phase field model of cell monolayers |
| work_keys_str_mv | AT grahamjn cellsortingbyactiveforcesinaphasefieldmodelofcellmonolayers AT zhangg cellsortingbyactiveforcesinaphasefieldmodelofcellmonolayers AT yeomansjm cellsortingbyactiveforcesinaphasefieldmodelofcellmonolayers |