Homodimerisation of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium

Homodimerisation of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium

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The lymphatic vessel endothelial receptor LYVE-1 is implicated in uptake of hyaluronan (HA) and trafficking of leucocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan, and depends on receptor clustering and higher-order ligand organisation for durable binding in lymphati...

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Detalles Bibliográficos
Main Authors: Banerji, S, Lawrance, W, Metcalfe, C, Briggs, D, Yamauchi, A, Dushek, O, van der Merwe, P, Day, A, Jackson, D
Formato: Journal article
Publicado: American Society for Biochemistry and Molecular Biology 2016

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