Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+.

Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+.

The effects of various stimulants of insulin release on cytosolic free Ca2+, [Ca2+]i, in dispersed and cultured pancreatic beta-cells from ob/ob-mice were studied using the indicator quin-2, which in itself has only slight effects on the glucose-induced insulin release and the metabolism of the suga...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Rorsman, P, Abrahamsson, H
Format:	Journal article
Sprog:	English
Udgivet:	1985

Lignende værker

CYCLIC-AMP POTENTIATION OF INSULIN RELEASE FROM PANCREATIC BETA-CELLS IS NOT MEDIATED BY AN INCREASED CYTOSOLIC CA-2+ ACTIVITY
af: Abrahamsson, H, et al.
Udgivet: (1984)

The dual action of glucose on the cytosolic Ca2+ activity in pancreatic beta-cells. Demonstration of an inhibitory effect of glucose on insulin release in the mouse and man.
af: Hellman, B, et al.
Udgivet: (1985)

Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells.
af: Rorsman, P, et al.
Udgivet: (1984)

DIRECT EVIDENCE THAT GLUCOSE BOTH REDUCES AND INCREASES CYTOSOLIC FREE CA-2+ IN MOUSE PANCREATIC BETA-CELLS
af: Rorsman, P, et al.
Udgivet: (1984)

Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose.
af: Rorsman, P, et al.
Udgivet: (1983)

Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion.
af: Hellman, B, et al.
Udgivet: (1980)

Insulin modulates the frequency of Ca2+ oscillations in mouse pancreatic islets.
af: Boah Lee, et al.
Udgivet: (2017-01-01)

Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells.
af: Ammälä, C, et al.
Udgivet: (1993)

Regulation of insulin secretion in human pancreatic islets.
af: Rorsman, P, et al.
Udgivet: (2013)

Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.
af: Craig S Nunemaker, et al.
Udgivet: (2009-12-01)

Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice.
af: Joung Woul Kim, et al.
Udgivet: (2008-05-01)

The DPP-IV inhibitor, sitgliptin enhances glucose-stimulated insulin secretion from mouse isolated islets
af: Clark, A, et al.
Udgivet: (2013)

Cyclic AMP stimulates insulin exocytosis by modification of granules already present at the release sites
af: Renstrom, E, et al.
Udgivet: (2001)

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release
af: Denwood, G, et al.
Udgivet: (2019)

EFFECTS OF CATIONIC MODIFICATION ON INTRACELLULAR UPTAKE AND SUPERFICIAL BINDING OF CA-45 BY DECAPSULATED OB/OB MOUSE PANCREATIC-ISLETS
af: Flatt, P, et al.
Udgivet: (1983)

EFFECTS OF CATIONIC MODIFICATION ON SUPERFICIAL BINDING AND INTRACELLULAR CA-45 UPTAKE BY DECAPSULATED OB/OB MOUSE PANCREATIC-ISLETS
af: Flatt, P, et al.
Udgivet: (1987)

CLONIDINE INHIBITION OF GLUCOSE-STIMULATED INSULIN-RELEASE INVOLVES REDUCTION OF THE CA-2+ CURRENT
af: Rorsman, P, et al.
Udgivet: (1987)

Expression of GABA(A) receptor Cl- channels and glucose-dependent GABA release in human pancreatic islets
af: Braun, M, et al.
Udgivet: (2006)

Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets
af: INÊS E BALDEIRAS, et al.
Udgivet: (2006-01-01)

Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas.
af: Abrahamsson, H, et al.
Udgivet: (1985)

Role of cyclic AMP and cyclic GMP as modulators of platelet cytosolic calcium
af: Gundu H.R. Rao
Udgivet: (2016-01-01)

MEMBRANE-POTENTIAL, TRANSMEMBRANE CA-45 FLUXES, CYTOPLASMIC FREE CA-2+ CONCENTRATION ([CA-2+]I) AND INSULIN RELEASE BY TRANSPLANTABLE RAT INSULINOMA CELLS
af: Flatt, P, et al.
Udgivet: (1988)

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans.
af: Rorsman, P, et al.
Udgivet: (2011)

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors.
af: Paola Llanos, et al.
Udgivet: (2015-01-01)

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.
af: Collins, S, et al.
Udgivet: (2008)

Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells.
af: Sylvain J Le Marchand, et al.
Udgivet: (2012-01-01)

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.
af: Smith, P, et al.
Udgivet: (1989)

Modelling of electrical activity in pancreatic islets: The role of a novel K-Ca-channel.
af: Galvanovskis, J, et al.
Udgivet: (2000)

Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.
af: Göpel, S, et al.
Udgivet: (2000)

Ca(2+)-induced Ca2+ release in insulin-secreting cells.
af: Islam, MS, et al.
Udgivet: (1992)

THE IMPORTANCE OF NA/CA-EXCHANGE IN RESTORING RESTING CYTOSOLIC CALCIUM LEVELS IN MOUSE BETA-CELLS
af: Bokvist, K, et al.
Udgivet: (1995)

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
af: Yi Cheng, et al.
Udgivet: (2023-11-01)

Effects of glucose, GLP-1 and adrenaline on alpha cell electrical activity and glucagon secretion from mouse pancreatic islets
af: Zhang, Q, et al.
Udgivet: (2010)

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice
af: Head W Steven, et al.
Udgivet: (2005-12-01)

Methylamine Activates Glucose Uptake in Human Adipocytes Without Overpassing Action of Insulin or Stimulating its Secretion in Pancreatic Islets
af: Christian Carpéné, et al.
Udgivet: (2019-08-01)

Depolarization-independent net uptake of calcium into clonal insulin-releasing cells exposed to glucose.
af: Gylfe, E, et al.
Udgivet: (1983)

Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic β-Cells.
af: Yuko Nakagawa, et al.
Udgivet: (2015-01-01)

Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism.
af: Larsson, R, et al.
Udgivet: (1984)

Correction: Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors [corrected].
af: Paola Llanos, et al.
Udgivet: (2015-01-01)

A pancreatic islet-specific microRNA regulates insulin secretion.
af: Poy, M, et al.
Udgivet: (2004)