Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malar...

Full description

Bibliographic Details
Main Authors:	Ndila, C, Uyoga, S, Macharia, A, Nyutu, G, Peshu, N, Ojal, J, Shebe, M, Awuondo, K, Mturi, N, Tsofa, B, Sepúlveda, N, Clark, T, Band, G, Clarke, G, Rowlands, K, Hubbart, C, Jeffreys, A, Kariuki, S, Marsh, K, Mackinnon, M, Maitland, K, Kwiatkowski, D, Rockett, K, Williams, T, Malariagen Consortium
Format:	Journal article
Language:	English
Published:	Elsevier 2018

Similar Items

Glucose-6-phosphate dehydrogenase deficiency and susceptibility to childhood diseases in Kilifi, Kenya
by: Uyoga, S, et al.
Published: (2020)

The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: A prospective cohort study
by: Uyoga, S, et al.
Published: (2019)

The indirect health effects of malaria estimated from health advantages of the sickle cell trait
by: Uyoga, S, et al.
Published: (2019)

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria
by: Opi, DH, et al.
Published: (2023)

Plasma Plasmodium falciparum Histidine-Rich Protein-2 concentrations in children with malaria infections of differing severity in Kilifi, Kenya
by: Uyoga, S, et al.
Published: (2020)

The clinical epidemiology of sickle cell anemia In Africa
by: Macharia, AW, et al.
Published: (2017)

The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study
by: Sophie Uyoga, PhD, et al.
Published: (2019-10-01)

Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.
by: D Herbert Opi, et al.
Published: (2023-09-01)

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children.
by: Atkinson, S, et al.
Published: (2014)

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children
by: Atkinson, S, et al.
Published: (2014)

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
by: Watson, JA, et al.
Published: (2021)

Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis.
by: Moïsi, J, et al.
Published: (2011)

Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data
by: Ndila, C, et al.
Published: (2021)

Environmental correlation analysis for genes associated with protection against malaria
by: Mackinnon, M, et al.
Published: (2016)

Profile: The Kilifi Health and Demographic Surveillance System (KHDSS).
by: Scott, J, et al.
Published: (2012)

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia
by: Herbert Opi, D, et al.
Published: (2018)

Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya
by: Malinga, J, et al.
Published: (2019)

Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya
by: Patricia Njuguna, et al.
Published: (2019-07-01)

Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis
by: Jennifer C Moïsi, et al.

The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
by: Uyoga, S, et al.
Published: (2022)

The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants
by: Macharia, A, et al.
Published: (2018)

The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
by: S. Uyoga, et al.
Published: (2022-06-01)

BIRC6 modifies risk of invasive bacterial infection in Kenyan children
by: Gilchrist, JJ, et al.
Published: (2022)

Invasive Salmonellosis in Kilifi, Kenya.
by: Muthumbi, E, et al.
Published: (2015)

Haplotype heterogeneity and low linkage disequilibrium reduce reliable prediction of genotypes for the ‑α3.7I form of α-thalassaemia using genome-wide microarray data [version 2; peer review: 2 approved]
by: Carolyne M. Ndila, et al.
Published: (2021-09-01)

Age, spatial and temporal variations in hospital admissions with malaria in Kilifi County, Kenya: A 25 year longitudinal observational study
by: Bejon, P, et al.
Published: (2016)

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision
by: James A Watson, et al.
Published: (2021-07-01)

Multi-centre analysis of the complex effects of G6PD deficiency on resistance to severe malaria
by: Clarke, G, et al.
Published: (2017)

Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya
by: Shah, S, et al.
Published: (2014)

Causes of death among persons of all ages within the Kilifi Health and Demographic Surveillance System, Kenya, determined from verbal autopsies interpreted using the InterVA-4 model
by: Carolyne Ndila, et al.
Published: (2014-10-01)

Malaria host candidate genes validated by association with current, recent, and historical measures of transmission intensity
by: Sepúlveda, N, et al.
Published: (2017)

BIRC6 modifies risk of invasive bacterial infection in Kenyan children
by: James J Gilchrist, et al.
Published: (2022-07-01)

Molecular epidemiology of Klebsiella pneumoniae invasive infections over a decade at Kilifi County Hospital in Kenya
by: Henson, S, et al.
Published: (2017)

Insights into malaria susceptibility using genome - wide data on 17,000 individuals from Africa, Asia and Oceania
by: Band, G, et al.
Published: (2019)

The clinical spectrum of severe childhood malaria in Eastern Uganda
by: Olupot-Olupot, P, et al.
Published: (2020)

Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya.
by: O'Meara, W, et al.
Published: (2008)

Malaria protection due to sickle haemoglobin depends on parasite genotype
by: Band, G, et al.
Published: (2021)

β-Thalassemia pathogenic variants in a cohort of children from the East African coast
by: Macharia, AW, et al.
Published: (2020)

A novel locus of resistance to severe malaria in a region of ancient balancing selection
by: Band, G, et al.
Published: (2015)

Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya
by: Njuguna, P, et al.
Published: (2019)