Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.

Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A.

Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation...

书目详细资料
Main Authors:	Nunes Bastos, R, Gandhi, SR, Baron, R, Gruneberg, U, Nigg, E, Barr, F
格式:	Journal article
语言:	English
出版:	2013

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