Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats.

BACKGROUND AND PURPOSE: Studies show that blocking the activation of caspases by the caspase inhibitors z-VAD.FMK and z-DEVD.FMK can reduce ischemic neuronal injury after cerebral ischemia. Because the severity of ischemia was mild in some studies, we tested the efficacy of these caspase inhibitors...

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Những tác giả chính: Li, H, Colbourne, F, Sun, P, Zhao, Z, Buchan, A, Iadecola, C
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2000