Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders.
BACKGROUND: The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder. AIMS: To examine the association between anxiety and course of bipolar disorder, as defined by mood episodes, quality of life and role functioning. METHOD: A thousand thousand out-pa...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2006
|
| _version_ | 1826295547718270976 |
|---|---|
| author | Otto, M Simon, N Wisniewski, SR Miklowitz, D Kogan, J Reilly-Harrington, N Frank, E Nierenberg, A Marangell, L Sagduyu, K Weiss, R Miyahara, S Thas, M Sachs, G Pollack, M |
| author_facet | Otto, M Simon, N Wisniewski, SR Miklowitz, D Kogan, J Reilly-Harrington, N Frank, E Nierenberg, A Marangell, L Sagduyu, K Weiss, R Miyahara, S Thas, M Sachs, G Pollack, M |
| author_sort | Otto, M |
| collection | OXFORD |
| description | BACKGROUND: The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder. AIMS: To examine the association between anxiety and course of bipolar disorder, as defined by mood episodes, quality of life and role functioning. METHOD: A thousand thousand out-patients with bipolar disorder were followed prospectively for 1 year. RESULTS: A current comorbid anxiety disorder (present in 31.9% of participants) was associated with fewer days well, a lower likelihood of timely recovery from depression, risk of earlier relapse, lower quality of life and diminished role function over I year of prospective study. The negative impact was greater with multiple anxiety disorders. CONCLUSIONS: Anxiety disorders, including those present during relative euthymia, predicted a poorer bipolar course. The detrimental effects of anxiety were not simply a feature of mood state. Treatment studies targeting anxiety disorders will help to clarify the nature of the impact of anxiety on bipolar course. |
| first_indexed | 2024-03-07T04:02:44Z |
| format | Journal article |
| id | oxford-uuid:c5232df6-d9e8-472d-a57b-4ff74bf2b3c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:02:44Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:c5232df6-d9e8-472d-a57b-4ff74bf2b3c12022-03-27T06:28:50ZProspective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c5232df6-d9e8-472d-a57b-4ff74bf2b3c1EnglishSymplectic Elements at Oxford2006Otto, MSimon, NWisniewski, SRMiklowitz, DKogan, JReilly-Harrington, NFrank, ENierenberg, AMarangell, LSagduyu, KWeiss, RMiyahara, SThas, MSachs, GPollack, M BACKGROUND: The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder. AIMS: To examine the association between anxiety and course of bipolar disorder, as defined by mood episodes, quality of life and role functioning. METHOD: A thousand thousand out-patients with bipolar disorder were followed prospectively for 1 year. RESULTS: A current comorbid anxiety disorder (present in 31.9% of participants) was associated with fewer days well, a lower likelihood of timely recovery from depression, risk of earlier relapse, lower quality of life and diminished role function over I year of prospective study. The negative impact was greater with multiple anxiety disorders. CONCLUSIONS: Anxiety disorders, including those present during relative euthymia, predicted a poorer bipolar course. The detrimental effects of anxiety were not simply a feature of mood state. Treatment studies targeting anxiety disorders will help to clarify the nature of the impact of anxiety on bipolar course. |
| spellingShingle | Otto, M Simon, N Wisniewski, SR Miklowitz, D Kogan, J Reilly-Harrington, N Frank, E Nierenberg, A Marangell, L Sagduyu, K Weiss, R Miyahara, S Thas, M Sachs, G Pollack, M Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. |
| title | Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. |
| title_full | Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. |
| title_fullStr | Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. |
| title_full_unstemmed | Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. |
| title_short | Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. |
| title_sort | prospective 12 month course of bipolar disorder in out patients with and without comorbid anxiety disorders |
| work_keys_str_mv | AT ottom prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT simonn prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT wisniewskisr prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT miklowitzd prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT koganj prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT reillyharringtonn prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT franke prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT nierenberga prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT marangelll prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT sagduyuk prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT weissr prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT miyaharas prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT thasm prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT sachsg prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders AT pollackm prospective12monthcourseofbipolardisorderinoutpatientswithandwithoutcomorbidanxietydisorders |