Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells by Ras. Rap1 is activated by several extracellular stimuli and may be involved in cellular processes such as cell proliferation, cell differentiation, T-cell anergy and p...

Descripció completa

Dades bibliogràfiques
Autors principals:	de Rooij, J, Zwartkruis, F, Verheijen, M, Cool, R, Nijman, S, Wittinghofer, A, Bos, J
Format:	Journal article
Idioma:	English
Publicat:	1998

Ítems similars

Identification and function of exchange proteins activated directly by cyclic AMP (Epac) in mammalian spermatozoa.
per: Alvaro Miro-Moran, et al.
Publicat: (2012-01-01)

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.
per: Ponsioen, B, et al.
Publicat: (2004)

Correction: The Rap1 Guanine Nucleotide Exchange Factor C3G Is Required for Preservation of Larval Muscle Integrity in.
per: Margret Shirinian, et al.
Publicat: (2010-01-01)

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling
per: Candice Sartre, et al.
Publicat: (2023-07-01)

The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.
per: Margret Shirinian, et al.
Publicat: (2010-03-01)

Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder.
per: Angela Bithell, et al.
Publicat: (2010-04-01)

Guanine nucleotide exchange factors and colon neoplasia
per: Lea-Pearl Njei, et al.
Publicat: (2024-10-01)

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
per: Antonio Rodríguez-Blázquez, et al.
Publicat: (2023-02-01)

Correction: The Rap1 Guanine Nucleotide Exchange Factor C3G Is Required for Preservation of Larval Muscle Integrity in Drosophila melanogaster
Publicat: (2010-01-01)

Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription
per: Liliana Felicia Iannucci, et al.
Publicat: (2023-09-01)

A nonsense variant in Rap Guanine Nucleotide Exchange Factor 5 (RAPGEF5) is associated with equine familial isolated hypoparathyroidism in Thoroughbred foals.
per: Victor N Rivas, et al.
Publicat: (2020-09-01)

Identification of a family of cAMP-binding guanine nucleotide exchange factors by Gregory M. Springett.
per: Springett, Gregory M., 1964-
Publicat: (2005)

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain
per: Kazuhiro Maeta, et al.
Publicat: (2018-05-01)

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.
per: Sarah V Consonni, et al.
Publicat: (2014-01-01)

Electrophysiological remodelling in human atrial cardiomyocyte: role of Exchange Proteins directly Activated by cAMP (EPAC)
per: Arthur Boileve, et al.
Publicat: (2024-11-01)

Scambio, a novel guanine nucleotide exchange factor for Rho
per: Groffen John, et al.
Publicat: (2004-04-01)

The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin.
per: K Farid Ahmad, et al.
Publicat: (2010-06-01)

Guanine Nucleotide Exchange Assay Using Fluorescent MANT-GDP
per: Tomoharu Kanie, et al.
Publicat: (2018-04-01)

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
per: Euan Parnell, et al.
Publicat: (2017-03-01)

TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells.
per: Aninda Mitra, et al.
Publicat: (2011-01-01)

Evaluation of Rap1GAP and EPAC1 gene expression in endometriosis disease
per: Mehran Dehghanian, et al.
Publicat: (2023-01-01)

EspM2 is a RhoA guanine nucleotide exchange factor
per: Arbeloa, A, et al.
Publicat: (2010)

EspM2 is a RhoA guanine nucleotide exchange factor
per: Lillington, J, et al.
Publicat: (2010)

Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice.
per: Reidun Aesoy, et al.
Publicat: (2018-01-01)

Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections
per: Eun-Jin Choi, et al.
Publicat: (2021-06-01)

Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.
per: B Josh Lane, et al.
Publicat: (2008-03-01)

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
per: Hocker, Harrison J., et al.
Publicat: (2013)

Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity
per: Marion Laudette, et al.
Publicat: (2021-09-01)

Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma
per: Shi J, et al.
Publicat: (2016-07-01)

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses
per: José L. Martínez, et al.
Publicat: (2020-06-01)

WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion
per: Guorui Huang, et al.
Publicat: (2017-07-01)

The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole.
per: María Eugenia Mansilla Pareja, et al.
Publicat: (2019-01-01)

Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement
per: Dhiman Sankar Pal, et al.
Publicat: (2023-07-01)

Structure-guided design of selective Epac1 and Epac2 agonists.
per: Frank Schwede, et al.
Publicat: (2015-01-01)

Epac Function and cAMP Scaffolds in the Heart and Lung
per: Marion Laudette, et al.
Publicat: (2018-02-01)

The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma
per: Alba Guijarro-Belmar, et al.
Publicat: (2021-01-01)

Host cell cAMP-Epac-Rap1b pathway inhibition by hawthorn extract as a potential target against Trypanosoma cruzi infection
per: Gabriel Ferri, et al.
Publicat: (2023-12-01)

Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF.
per: Takuro Horii, et al.
Publicat: (2009-06-01)

The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
per: Thomas Samson, et al.
Publicat: (2013-01-01)

The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin
per: Fluharty Eric, et al.
Publicat: (2003-09-01)