NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.
Base excision repair is the major pathway for the repair of oxidative DNA damage in human cells that is initiated by a damage-specific DNA glycosylase. In human cells, the major DNA glycosylases for the excision of oxidative base damage are OGG1 and NTH1 that excise 8-oxoguanine and oxidative pyrimi...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797093626824622080 |
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| author | Parsons, J Zharkov, DO Dianov, G |
| author_facet | Parsons, J Zharkov, DO Dianov, G |
| author_sort | Parsons, J |
| collection | OXFORD |
| description | Base excision repair is the major pathway for the repair of oxidative DNA damage in human cells that is initiated by a damage-specific DNA glycosylase. In human cells, the major DNA glycosylases for the excision of oxidative base damage are OGG1 and NTH1 that excise 8-oxoguanine and oxidative pyrimidines, respectively. We find that both enzymes have limited activity on DNA lesions located in the vicinity of the 3' end of a DNA single-strand break, suggesting that other enzymes are involved in the processing of such lesions. In this study, we identify and characterize NEIL1 as a major DNA glycosylase that excises oxidative base damage located in close proximity to the 3' end of a DNA single-strand break. |
| first_indexed | 2024-03-07T04:02:59Z |
| format | Journal article |
| id | oxford-uuid:c53a393f-6b4e-416b-bc33-9f380f9d474e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:02:59Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:c53a393f-6b4e-416b-bc33-9f380f9d474e2022-03-27T06:29:14ZNEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c53a393f-6b4e-416b-bc33-9f380f9d474eEnglishSymplectic Elements at Oxford2005Parsons, JZharkov, DODianov, GBase excision repair is the major pathway for the repair of oxidative DNA damage in human cells that is initiated by a damage-specific DNA glycosylase. In human cells, the major DNA glycosylases for the excision of oxidative base damage are OGG1 and NTH1 that excise 8-oxoguanine and oxidative pyrimidines, respectively. We find that both enzymes have limited activity on DNA lesions located in the vicinity of the 3' end of a DNA single-strand break, suggesting that other enzymes are involved in the processing of such lesions. In this study, we identify and characterize NEIL1 as a major DNA glycosylase that excises oxidative base damage located in close proximity to the 3' end of a DNA single-strand break. |
| spellingShingle | Parsons, J Zharkov, DO Dianov, G NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. |
| title | NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. |
| title_full | NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. |
| title_fullStr | NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. |
| title_full_unstemmed | NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. |
| title_short | NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1. |
| title_sort | neil1 excises 3 end proximal oxidative dna lesions resistant to cleavage by nth1 and ogg1 |
| work_keys_str_mv | AT parsonsj neil1excises3endproximaloxidativednalesionsresistanttocleavagebynth1andogg1 AT zharkovdo neil1excises3endproximaloxidativednalesionsresistanttocleavagebynth1andogg1 AT dianovg neil1excises3endproximaloxidativednalesionsresistanttocleavagebynth1andogg1 |