Large-scale data analysis on endometriosis from the UK Biobank reveals novel genetic loci

Large-scale data analysis on endometriosis from the UK Biobank reveals novel genetic loci

Endometriosis is a common complex condition with an estimated heritability of 50%. The largest meta-analysis of genome-wide association studies (GWAS) for endometriosis to date, including 17K cases, identified 14 genome-wide significant loci (p<5x10-8) together explaining only 5% of the herit...

Podrobná bibliografie
Hlavní autoři:	Rahmioglu, N, Cook, J, Becker, C, Morris, A, Zondervan, K
Médium:	Conference item
Vydáno:	SAGE Publications 2018

Podobné jednotky

Discovery of novel loci for endometriosis in genome-wide association analysis of 63 K cases and 700 K controls
Autor: Rahmioglu, N, a další
Vydáno: (2018)

Understanding endometriosis heterogeneity—subphenotype analysis of genetic associations
Autor: Cheuk, S, a další
Vydáno: (2018)

Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci.
Autor: Rahmioglu, N, a další
Vydáno: (2014)

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: IV. Tissue collection, processing, and storage in endometriosis research.
Autor: Fassbender, A, a další
Vydáno: (2014)

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research.
Autor: Rahmioglu, N, a další
Vydáno: (2014)

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: II. Clinical and covariate phenotype data collection in endometriosis research.
Autor: Vitonis, A, a další
Vydáno: (2014)

Crimson clues: advancing endometriosis detection and management with novel blood biomarkers
Autor: Gibbons, T, a další
Vydáno: (2024)

Insights into Assessing the Genetics of Endometriosis.
Autor: Rahmioglu, N, a další
Vydáno: (2012)

Genome-wide association analysis identifies 27 novel loci associated with uterine leiomyomata revealing common genetic origins with endometriosis
Autor: Gallagher, C, a další
Vydáno: (2018)

Identification of sex-specific pleiotropic loci underlying endometriosis and obesity-related traits
Autor: Rahmioglu, N, a další
Vydáno: (2013)

World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research.
Autor: Becker, C, a další
Vydáno: (2014)

Common genetic variants underlie endometriosis and obesity-related traits
Autor: Rahmioglu, N, a další
Vydáno: (2012)

Genome-wide genetic analyses highlight MAPK signalling in the pathogenesis of endometriosis
Autor: UImari, O, a další
Vydáno: (2017)

Large-scale integrated genome-wide RNA sequencing, miRNA array, and genomic analyses to unravel the functionality of genome-wide association results in endometriosis
Autor: Rahmioglu, N, a další
Vydáno: (2017)

Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis
Autor: Uimari, O, a další
Vydáno: (2017)

Beyond endometriosis genome-wide association study: from genomics to phenomics to the patient
Autor: Zondervan, K, a další
Vydáno: (2016)

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets.
Autor: Rahmioglu, N, a další
Vydáno: (2014)

Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes
Autor: Chia-Jung Lee, a další
Vydáno: (2022-11-01)

Identification of thirty novel loci for cardiovascular magnetic resonance derived aortic distensibility in the UK Biobank
Autor: Fung, K, a další
Vydáno: (2021)

Peripheral basophil count is increased in patients with endometriosis
Autor: Feng, Q, a další
Vydáno: (2018)

The miRNA mirage: How close are we to finding a non-invasive diagnostic biomarker in endometriosis? A systematic review.
Autor: Agrawal, S, a další
Vydáno: (2018)

Bioinformatic and rare‐variant collapsing analyses for type 1 and type 2 diabetes in the UK Biobank reveal novel pleiotropic susceptibility loci
Autor: Bengt Zöller, a další
Vydáno: (2023-09-01)

The genetic basis of endometriosis.
Autor: Zondervan, K, a další
Vydáno: (2001)

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Autor: Rahmioglu, N, a další
Vydáno: (2023)

The predictive potential of peripheral blood basophils in endometriosis
Autor: Guan, J, a další
Vydáno: (2017)

Endometriosis
Autor: Zondervan, KT, a další
Vydáno: (2020)

A novel deep learning method for large-scale analysis of bone marrow adiposity using UK Biobank Dixon MRI data
Autor: David M. Morris, a další
Vydáno: (2024-12-01)

Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort.
Autor: Tamara Ashvetiya, a další
Vydáno: (2021-01-01)

Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression
Autor: Ruoyu Tian, a další
Vydáno: (2024-02-01)

How UK Biobank is democratising access to large-scale genomic and phenotypic data for discovery science
Autor: Lacey, B, a další
Vydáno: (2022)

Chapeau UK Biobank! A revolution for integrated research on humans and large-scale data sharing
Autor: Bourgeron, Thomas
Vydáno: (2022-05-01)

Genetic predisposition to tinnitus in the UK Biobank population
Autor: Madeleine E. Urbanek, a další
Vydáno: (2021-09-01)

Designing studies into the genetic epidemiology of endometriosis.
Autor: Zondervan, K, a další
Vydáno: (2002)

Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data
Autor: Peilin Meng, a další
Vydáno: (2022-01-01)

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
Autor: Sapkota, Y, a další
Vydáno: (2017)

Endometriosis: the authors reply
Autor: Becker, CM, a další
Vydáno: (2020)

UK BIOBANK: THE NEED FOR LARGE PROSPECTIVE EPIDEMIOLOGICAL STUDIES
Autor: Collins, R
Vydáno: (2011)

Elevated basophil count is associated with increased risk of endometriosis
Autor: Feng, Q, a další
Vydáno: (2024)

Genetic predictors of participation in optional components of UK Biobank
Autor: Jessica Tyrrell, a další
Vydáno: (2021-02-01)

Elevated basophil count is associated with increased odds of endometriosis
Autor: Qian Feng, a další
Vydáno: (2024-08-01)