A basic helix-loop-helix transcription factor controls cell growth and size in root hairs
Postmitotic cell growth defines cell shape and size during development. However, the mechanisms regulating postmitotic cell growth in plants remain unknown. Here we report the discovery of a basic helix-loop-helix (bHLH) transcription factor called RSL4 (ROOT HAIR DEFECTIVE 6-LIKE 4) that is suffici...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Nature Publishing Group
2010
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| Subjects: |
| _version_ | 1826295602394169344 |
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| author | Yi, K Menand, B Bell, E Dolan, L |
| author_facet | Yi, K Menand, B Bell, E Dolan, L |
| author_sort | Yi, K |
| collection | OXFORD |
| description | Postmitotic cell growth defines cell shape and size during development. However, the mechanisms regulating postmitotic cell growth in plants remain unknown. Here we report the discovery of a basic helix-loop-helix (bHLH) transcription factor called RSL4 (ROOT HAIR DEFECTIVE 6-LIKE 4) that is sufficient to promote postmitotic cell growth in <em>Arabidopsis thaliana</em> root-hair cells. Loss of RSL4 function resulted in the development of very short root hairs. In contrast, constitutive RSL4 expression programmed constitutive growth, resulting in the formation of very long root hairs. Hair-cell growth signals, such as auxin and low phosphate availability, modulate hair cell extension by regulating RSL4 transcript and protein levels. RSL4 is thus a regulator of growth that integrates endogenous developmental and exogenous environmental signals that together control postmitotic growth in root hairs. The control of postmitotic growth by transcription factors may represent a general mechanism for regulating cell size across diverse organisms. |
| first_indexed | 2024-03-07T04:03:34Z |
| format | Journal article |
| id | oxford-uuid:c567186d-f39a-424a-a342-b613bc58bc15 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:03:34Z |
| publishDate | 2010 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:c567186d-f39a-424a-a342-b613bc58bc152022-03-27T06:30:34ZA basic helix-loop-helix transcription factor controls cell growth and size in root hairsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c567186d-f39a-424a-a342-b613bc58bc15Plant SciencesEnglishOxford University Research Archive - ValetNature Publishing Group2010Yi, KMenand, BBell, EDolan, LPostmitotic cell growth defines cell shape and size during development. However, the mechanisms regulating postmitotic cell growth in plants remain unknown. Here we report the discovery of a basic helix-loop-helix (bHLH) transcription factor called RSL4 (ROOT HAIR DEFECTIVE 6-LIKE 4) that is sufficient to promote postmitotic cell growth in <em>Arabidopsis thaliana</em> root-hair cells. Loss of RSL4 function resulted in the development of very short root hairs. In contrast, constitutive RSL4 expression programmed constitutive growth, resulting in the formation of very long root hairs. Hair-cell growth signals, such as auxin and low phosphate availability, modulate hair cell extension by regulating RSL4 transcript and protein levels. RSL4 is thus a regulator of growth that integrates endogenous developmental and exogenous environmental signals that together control postmitotic growth in root hairs. The control of postmitotic growth by transcription factors may represent a general mechanism for regulating cell size across diverse organisms. |
| spellingShingle | Plant Sciences Yi, K Menand, B Bell, E Dolan, L A basic helix-loop-helix transcription factor controls cell growth and size in root hairs |
| title | A basic helix-loop-helix transcription factor controls cell growth and size in root hairs |
| title_full | A basic helix-loop-helix transcription factor controls cell growth and size in root hairs |
| title_fullStr | A basic helix-loop-helix transcription factor controls cell growth and size in root hairs |
| title_full_unstemmed | A basic helix-loop-helix transcription factor controls cell growth and size in root hairs |
| title_short | A basic helix-loop-helix transcription factor controls cell growth and size in root hairs |
| title_sort | basic helix loop helix transcription factor controls cell growth and size in root hairs |
| topic | Plant Sciences |
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