The thiopurine methyltransferase TPMT *1/*3A genotype is associated with a better treatment outcome in the UK ALL97 trial for childhood acute lymphoblastic leukaemia; TPMT heterozygosity is not associated with secondary cancers

The thiopurine methyltransferase TPMT 1/3A genotype is associated with a better treatment outcome in the UK ALL97 trial for childhood acute lymphoblastic leukaemia; TPMT heterozygosity is not associated with secondary cancers

Détails bibliographiques
Auteurs principaux:	Lennard, L, Cartwright, C, Wade, R, Richards, S, Mitchell, C, Kinsey, S, Eden, T, Lilleyman, J, Vora, A
Format:	Conference item
Publié:	2010

Documents similaires

Detection of Thiopurine S-Methyltransferase (TPMT) Polymorphisms TPMT*3A, TPMT*3B and TPMT*3C in Children with Acute Lymphoblastic Leukemia
par: Nawar S. Mohammed, et autres
Publié: (2018-12-01)

Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.
par: Lennard, L, et autres
Publié: (2013)

Common Polymorphism’s Analysis of Thiopurine S-Methyltransferase (TPMT) in Iranian Population
par: Mehdi Azad, et autres
Publié: (2009-01-01)

In Vitro Protein Stability of Two Naturally Occurring Thiopurine S‑Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8
par: Patricia Wennerstrand, et autres
Publié: (2017-08-01)

Thiopurine methyltransferase (TPMT), nudix hydrolase 15 (NUDT-15) and methylene tetrahydrofolate reductase (MTHFR)polymorphisms in children with acute lymphoblastic leukaemia
par: Srikanth Marda, et autres
Publié: (2022-01-01)

Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing
par: Hui-min, Neoh, et autres
Publié: (2012)

ASSOCIATION BETWEEN GENETIC VARIANTS IN TPMT AND NUDT15 AND THIOPURINE TOXICITY IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
par: A Nagel, et autres
Publié: (2024-10-01)

The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia.
par: Lennard, L, et autres
Publié: (2006)

The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn’s Disease
par: Ha C, et autres
Publié: (2020-11-01)

Thioguanine versus mercaptopurine in ALL97: thiopurine metabolism and treatment outcome
par: Lennard, L, et autres
Publié: (2008)

Thioguanine compared with mercaptopurine in childhood lymphoblastic leukaemia: Results of the United Kingdom medical research council randomised trial ALL97.
par: Lennard, L, et autres
Publié: (2005)

Thiopurine S-methyl Transferase (TPMT) Enzyme Level in Healthy Sudanese Population
par: Rayan Khalid, et autres
Publié: (2024-09-01)

The clinical pharmacology of thioguanine vs. mercaptopurine in ALL97, a randomized trial for the treatment of childhood lymphoblastic leukaemia
par: Lennard, L, et autres
Publié: (2008)

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia.
par: McLeod, H, et autres
Publié: (1999)

Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics.
par: Antoine Neuraz, et autres
Publié: (2013-01-01)

Thioguanine-related veno-occlusive disease (VOD) of the liver in children with acute lymphoblastic leukaemia (ALL): Report from United Kingdom Medical Research Council (UK MRC) trial ALL97.
par: Vora, A, et autres
Publié: (2002)

Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial.
par: Mitchell, C, et autres
Publié: (2005)

LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity
par: Amol O. Bajaj, et autres
Publié: (2022-03-01)

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT
par: Yoomi Park, et autres
Publié: (2020-07-01)

TPMT and NUDT15 testing for thiopurine therapy: A major tertiary hospital experience and lessons learned
par: Liuh Ling Goh, et autres
Publié: (2022-09-01)

Benefit of targeted intensification for NCI high risk childhood lymphoblastic leukaemia: Results of the United Kingdom medical research council trial ALL97 and ALL97/99.
par: Vora, A, et autres
Publié: (2006)

Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study
par: Amine Benmassaoud, et autres
Publié: (2016-01-01)

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial.
par: Vora, A, et autres
Publié: (2006)

Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia
par: NAWARS MOHAMMED, et autres
Publié: (2019-01-01)

TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy
par: Rosdiana DS, et autres
Publié: (2021-02-01)

The impact of risk stratification by early bone-marrow response in childhood lymphoblastic leukaemia: results from the United Kingdom Medical Research Council trial ALL97 and ALL97/99.
par: Mitchell, C, et autres
Publié: (2009)

ITPA polymorphisms do not predict additional risk beyond TPMT and NUDT15 for thiopurine-induced cytopenia in inflammatory bowel disease
par: A. Jena, et autres
Publié: (2024-01-01)

Variables affecting kinetics of minimal residual disease clearance in children with lymphoblastic leukaemia; Results of the United Kingdom Medical Research Council (UK MRC) protocols ALL97, ALL97/99 and ALL2003.
par: Vora, A, et autres
Publié: (2005)

Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia.
par: Hann, I, et autres
Publié: (2000)

Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia.
par: Escherich, G, et autres
Publié: (2011)

Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia
par: Gabriela Burgueño-Rodríguez, et autres
Publié: (2020-11-01)

Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia
par: Escherich, G, et autres
Publié: (2011)

Association of TPMT (rs1800460) Gene Polymorphism with Childhood Acute Lymphoblastic Leukemia in a Population from Guilan, Iran
par: Mohammad Hedayati, et autres
Publié: (2020-09-01)

Implications of Tioguanine Dosing in IBD Patients with a TPMT Deficiency
par: Debbie S. Deben, et autres
Publié: (2023-10-01)

Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT
par: Hyery Kim, et autres
Publié: (2021-05-01)

P044: Pharmacogenetic profile for NUDT15 and TPMT in a Peruvian population with pediatric acute lymphoblastic leukemia
par: Jeny Bazalar-Montoya, et autres
Publié: (2023-01-01)

Intraocular relapse of childhood acute lymphoblastic leukaemia.
par: Somervaille, T, et autres
Publié: (2003)

Late relapsing childhood lymphoblastic leukaemia.
par: Frost, L, et autres
Publié: (1997)

Late relapsing childhood acute lymphoblastic leukaemia.
par: Frost, L, et autres
Publié: (1998)

NUDT15 and TPMT polymorphisms in three distinct native populations of the Brazilian Amazon
par: Jamila Alessandra Perini, et autres
Publié: (2024-02-01)