Costimulation via CD55 on human CD4+ T cells mediated by CD97.
Decay-accelerating factor (CD55) is a complement regulatory protein, which is expressed by most cells to protect them from complement-mediated attack. CD55 also binds CD97, an EGF-TM7 receptor constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells upon activ...
| Autores principales: | , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2006
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| _version_ | 1826295610273169408 |
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| author | Capasso, M Durrant, L Stacey, M Gordon, S Ramage, J Spendlove, I |
| author_facet | Capasso, M Durrant, L Stacey, M Gordon, S Ramage, J Spendlove, I |
| author_sort | Capasso, M |
| collection | OXFORD |
| description | Decay-accelerating factor (CD55) is a complement regulatory protein, which is expressed by most cells to protect them from complement-mediated attack. CD55 also binds CD97, an EGF-TM7 receptor constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells upon activation. Early results suggested that CD55 could further enhance T cell proliferation induced by phorbol ester treatment. The present study demonstrates that coengagement of CD55, using either cross-linking mAbs or its natural ligand CD97, and CD3 results in enhanced proliferation of human peripheral blood CD4(+) T cells, expression of the activation markers CD69 and CD25, and secretion of IL-10 and GM-CSF. Recently, an increase in T cell responsiveness in CD55(-/-) mice was shown to be mediated by a lack of complement regulation. In this study, we show that direct stimulation of CD55 on CD4(+) T cells with CD97 can modulate T cell activation but does not interfere with CD55-mediated complement regulation. Our results support a multifaceted role for CD55 in human T cell activation, constituting a further link between innate and adaptive immunity. |
| first_indexed | 2024-03-07T04:03:41Z |
| format | Journal article |
| id | oxford-uuid:c5705f1a-6472-49b3-b478-7001eeaa4f4a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:03:41Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:c5705f1a-6472-49b3-b478-7001eeaa4f4a2022-03-27T06:30:54ZCostimulation via CD55 on human CD4+ T cells mediated by CD97.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c5705f1a-6472-49b3-b478-7001eeaa4f4aEnglishSymplectic Elements at Oxford2006Capasso, MDurrant, LStacey, MGordon, SRamage, JSpendlove, IDecay-accelerating factor (CD55) is a complement regulatory protein, which is expressed by most cells to protect them from complement-mediated attack. CD55 also binds CD97, an EGF-TM7 receptor constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells upon activation. Early results suggested that CD55 could further enhance T cell proliferation induced by phorbol ester treatment. The present study demonstrates that coengagement of CD55, using either cross-linking mAbs or its natural ligand CD97, and CD3 results in enhanced proliferation of human peripheral blood CD4(+) T cells, expression of the activation markers CD69 and CD25, and secretion of IL-10 and GM-CSF. Recently, an increase in T cell responsiveness in CD55(-/-) mice was shown to be mediated by a lack of complement regulation. In this study, we show that direct stimulation of CD55 on CD4(+) T cells with CD97 can modulate T cell activation but does not interfere with CD55-mediated complement regulation. Our results support a multifaceted role for CD55 in human T cell activation, constituting a further link between innate and adaptive immunity. |
| spellingShingle | Capasso, M Durrant, L Stacey, M Gordon, S Ramage, J Spendlove, I Costimulation via CD55 on human CD4+ T cells mediated by CD97. |
| title | Costimulation via CD55 on human CD4+ T cells mediated by CD97. |
| title_full | Costimulation via CD55 on human CD4+ T cells mediated by CD97. |
| title_fullStr | Costimulation via CD55 on human CD4+ T cells mediated by CD97. |
| title_full_unstemmed | Costimulation via CD55 on human CD4+ T cells mediated by CD97. |
| title_short | Costimulation via CD55 on human CD4+ T cells mediated by CD97. |
| title_sort | costimulation via cd55 on human cd4 t cells mediated by cd97 |
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