Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.

Obesity is a major health problem, and many family-based studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing BMI in 573 pedigrees from the U.K. We identified genome-wide significant linkage (logarithm of odds = 3....

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Groves, C, Zeggini, E, Walker, M, Hitman, G, Levy, J, O'Rahilly, S, Hattersley, A, McCarthy, M, Wiltshire, S
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2006

समान संसाधन

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Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
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Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24.
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Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
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Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
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Significant linkage to migraine with aura on chromosome 11q24.
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Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
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Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
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प्रकाशित: (1997)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
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Linkage disequilibrium mapping of the type 2 diabetes susceptibility variants on chromosome Iq in European populations
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प्रकाशित: (2005)

Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q
द्वारा: Prokopenko, I, और अन्य
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Evaluating the results of genomewide linkage scans of complex traits by locus counting.
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Common variation in the LMNA gene increases susceptibility to type 2 diabetes
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A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.
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How useful is the fine-scale mapping of complex trait linkage peaks? Evaluating the impact of additional microsatellite genotyping on the posterior probability of linkage.
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Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q.
द्वारा: Larsen, F, और अन्य
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Testing candidate loci on chromosomes 1 and 6 for genetic linkage to Peutz-Jeghers' disease.
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प्रकाशित: (1996)

Linkage to the AUTS1 locus and analysis of candidate genes for autism on chromosome 7q.
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Evaluating results from genome-wide linkage scans of complex discrete traits by locus counting.
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BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study
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High-density association mapping and comprehensive tagging of the type 2 diabetes linkage region on chromosome 1q in 4 European populations
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Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss
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