Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.
A healthy individual can mount an immune response to exogenous pathogens while avoiding an autoimmune attack on normal tissues. The ability to distinguish between self and non-self is called 'immunological tolerance' and, for T lymphocytes, involves the generation of a diverse pool of func...
Main Authors: | Daniels, M, Teixeiro, E, Gill, J, Hausmann, B, Roubaty, D, Holmberg, K, Werlen, G, Holländer, G, Gascoigne, N, Palmer, E |
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格式: | Journal article |
语言: | English |
出版: |
2006
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