Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

Endotoxin signaling in human macrophages: signaling via an alternate mechanism.

Lipopolysaccharide (LPS) signals through Toll-like receptors (TLRs) in the course of sepsis, resulting in the release of inflammatory factors. In cell lines and murine models, parts of the signaling pathways involved have been elucidated with MyD88, Mal/TIRAP and IKK2 playing an important role in th...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Sacre, S, Andreakos, E, Feldmann, M, Foxwell, B
Materialtyp:	Journal article
Språk:	English
Publicerad:	2004

Liknande verk

Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
av: Sacre, S, et al.
Publicerad: (2007)

Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
av: Andreakos, E, et al.
Publicerad: (2004)

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
av: Andreakos, E, et al.
Publicerad: (2005)

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.
av: Wales, J, et al.
Publicerad: (2007)

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination
av: Wales, J, et al.
Publicerad: (2007)

Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
av: Sacre, S, et al.
Publicerad: (2007)

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
av: Ciesielski, C, et al.
Publicerad: (2002)

TNFα-induced macrophage chemokine secretion is more dependent on NF-κB expression than lipopolysaccharides-induced macrophage chemokine secretion
av: Ciesielski, C, et al.
Publicerad: (2002)

Molecular therapeutic targets in rheumatoid arthritis.
av: Sacre, S, et al.
Publicerad: (2005)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
av: Kiriakidis, S, et al.
Publicerad: (2003)

VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
av: Kiriakidis, S, et al.
Publicerad: (2003)

Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
av: Andreakos, E, et al.
Publicerad: (2004)

Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.
av: Lundberg, A, et al.
Publicerad: (2007)

The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
av: Sacre, S, et al.
Publicerad: (2007)

Cytokine receptors: structure and signal transduction.
av: Foxwell, B, et al.
Publicerad: (1992)

Targeting intracellular signaling: a novel approach to vaccination.
av: Wales, J, et al.
Publicerad: (2007)

Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes.
av: Turner, J, et al.
Publicerad: (2010)

Endotoxin Disrupts Circadian Rhythms in Macrophages via Reactive Oxygen Species.
av: Yusi Wang, et al.
Publicerad: (2016-01-01)

T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.
av: Monaco, C, et al.
Publicerad: (2002)

NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts
av: Smith, C, et al.
Publicerad: (2001)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
av: Smith, C, et al.
Publicerad: (2001)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
av: Andreakos, E, et al.
Publicerad: (2006)

Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
av: Andreakos, E, et al.
Publicerad: (2002)

T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.
av: Monaco, C, et al.
Publicerad: (2004)

Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.
av: Conron, M, et al.
Publicerad: (2001)

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.
av: Gasparini, C, et al.
Publicerad: (2013)

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages
av: Gasparini, C, et al.
Publicerad: (2013)

Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.
av: Foxwell, B, et al.
Publicerad: (2003)

Non-Genomic AhR-Signaling Modulates the Immune Response in Endotoxin-Activated Macrophages After Activation by the Environmental Stressor BaP
av: Henning Großkopf, et al.
Publicerad: (2021-03-01)

IκB kinase 2 but not NF-κB-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction
av: Andreakos, E, et al.
Publicerad: (2003)

Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
av: Andreakos, E, et al.
Publicerad: (2003)

Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
av: Monaco, C, et al.
Publicerad: (2004)

Utilisation of fatty acid and triacylglycerol by rat macrophages: the effect of endotoxin.
av: Hauton, D, et al.
Publicerad: (2002)

Sufficient production of geranylgeraniol is required to maintain endotoxin tolerance in macrophages
av: Jinyong Kim, et al.
Publicerad: (2013-12-01)

Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection
av: Xue Zhang, et al.
Publicerad: (2022-08-01)

Advanced glycation end products (AGEs) augment production of vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF alpha) in human monocyte-derived macrophages.
av: Pertynska-Marczewska, M, et al.
Publicerad: (2003)

Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.
av: Drexler, S, et al.
Publicerad: (2010)

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
av: Sacre, S, et al.
Publicerad: (2008)

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
av: Sacre, S, et al.
Publicerad: (2009)

High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
av: Horwood, N, et al.
Publicerad: (2002)