Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation.
Metallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showe...
| Үндсэн зохиолчид: | , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
1988
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| _version_ | 1826295637871689728 |
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| author | Hanke, T Tyers, M Harley, C |
| author_facet | Hanke, T Tyers, M Harley, C |
| author_sort | Hanke, T |
| collection | OXFORD |
| description | Metallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showed similar basal levels of MT RNA with significant induction following exposure to Cd2+ but not activators of PKC. MT RNA did not correlate with growth state or with known levels of PKC activity, thus our data do not support a role for MT in HL-60 differentiation or for PKC in MT expression. |
| first_indexed | 2024-03-07T04:04:07Z |
| format | Journal article |
| id | oxford-uuid:c58e98d0-f0f9-44d1-b80f-92e9b8d9576d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:04:07Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:c58e98d0-f0f9-44d1-b80f-92e9b8d9576d2022-03-27T06:32:01ZMetallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c58e98d0-f0f9-44d1-b80f-92e9b8d9576dEnglishSymplectic Elements at Oxford1988Hanke, TTyers, MHarley, CMetallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showed similar basal levels of MT RNA with significant induction following exposure to Cd2+ but not activators of PKC. MT RNA did not correlate with growth state or with known levels of PKC activity, thus our data do not support a role for MT in HL-60 differentiation or for PKC in MT expression. |
| spellingShingle | Hanke, T Tyers, M Harley, C Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation. |
| title | Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation. |
| title_full | Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation. |
| title_fullStr | Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation. |
| title_full_unstemmed | Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation. |
| title_short | Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation. |
| title_sort | metallothionein rna levels in hl 60 cells effect of cadmium differentiation and protein kinase c activation |
| work_keys_str_mv | AT hanket metallothioneinrnalevelsinhl60cellseffectofcadmiumdifferentiationandproteinkinasecactivation AT tyersm metallothioneinrnalevelsinhl60cellseffectofcadmiumdifferentiationandproteinkinasecactivation AT harleyc metallothioneinrnalevelsinhl60cellseffectofcadmiumdifferentiationandproteinkinasecactivation |