An amphioxus Krox gene: insights into vertebrate hindbrain evolution.
The transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Kr...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1797093704372060160 |
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| author | Knight, R Panopoulou, G Holland, P Shimeld, S |
| author_facet | Knight, R Panopoulou, G Holland, P Shimeld, S |
| author_sort | Knight, R |
| collection | OXFORD |
| description | The transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Krox-20 are also derived, we cloned a Krox-20 related gene, AmphiKrox, from amphioxus. AmphiKrox is related to a small family of vertebrate Krox genes and is expressed in the most anterior region of the amphioxus brain and in the club shaped gland, a secretory organ that develops in the anterior pharynx. Neither expression domain overlaps with the expression of AmphiHox-1, -2, -3 or -4, suggesting that the roles of Krox-20 in hindbrain segmentation and in Hox gene regulation were acquired concomitant with the duplication of Krox genes in vertebrate evolution. |
| first_indexed | 2024-03-07T04:04:09Z |
| format | Journal article |
| id | oxford-uuid:c590f7a6-4d41-41f7-bd41-6cdd0f07bd97 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:04:09Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:c590f7a6-4d41-41f7-bd41-6cdd0f07bd972022-03-27T06:31:58ZAn amphioxus Krox gene: insights into vertebrate hindbrain evolution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c590f7a6-4d41-41f7-bd41-6cdd0f07bd97EnglishSymplectic Elements at Oxford2000Knight, RPanopoulou, GHolland, PShimeld, SThe transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Krox-20 are also derived, we cloned a Krox-20 related gene, AmphiKrox, from amphioxus. AmphiKrox is related to a small family of vertebrate Krox genes and is expressed in the most anterior region of the amphioxus brain and in the club shaped gland, a secretory organ that develops in the anterior pharynx. Neither expression domain overlaps with the expression of AmphiHox-1, -2, -3 or -4, suggesting that the roles of Krox-20 in hindbrain segmentation and in Hox gene regulation were acquired concomitant with the duplication of Krox genes in vertebrate evolution. |
| spellingShingle | Knight, R Panopoulou, G Holland, P Shimeld, S An amphioxus Krox gene: insights into vertebrate hindbrain evolution. |
| title | An amphioxus Krox gene: insights into vertebrate hindbrain evolution. |
| title_full | An amphioxus Krox gene: insights into vertebrate hindbrain evolution. |
| title_fullStr | An amphioxus Krox gene: insights into vertebrate hindbrain evolution. |
| title_full_unstemmed | An amphioxus Krox gene: insights into vertebrate hindbrain evolution. |
| title_short | An amphioxus Krox gene: insights into vertebrate hindbrain evolution. |
| title_sort | amphioxus krox gene insights into vertebrate hindbrain evolution |
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