A Human Recombinant Autoantibody-Based Immunotoxin Specific for the Fetal Acetylcholine Receptor Inhibits Rhabdomyosarcoma Growth In Vitro and in a Murine Transplantation Model

A Human Recombinant Autoantibody-Based Immunotoxin Specific for the Fetal Acetylcholine Receptor Inhibits Rhabdomyosarcoma Growth In Vitro and in a Murine Transplantation Model

Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumor in children and is highly resistant to all forms of treatment currently available once metastasis or relapse has commenced. As it has recently been determined that the acetylcholine receptor (AChR) γ-subunit, which defines the fet...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Gattenloehner, S, Joerissen, H, Huhn, M, Vincent, A, Beeson, D, Tzartos, S, Mamalaki, A, Etschmann, B, Muller-Hermelink, H, Koscielniak, E, Barth, S, Marx, A
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

Eitemau Tebyg

Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric receptor targeting the fetal acetylcholine receptor.
gan: Gattenlöhner, S, et al.
Cyhoeddwyd: (2006)

Targeting the fetal acetylcholine receptor in rhabdomyosarcoma.
gan: Simon-Keller, K, et al.
Cyhoeddwyd: (2013)

Isolation of potent human Fab fragments against a novel highly immunogenic region on human muscle acetylcholine receptor which protect the receptor from myasthenic autoantibodies.
gan: Fostieri, E, et al.
Cyhoeddwyd: (2005)

Survivin blockade sensitizes rhabdomyosarcoma cells for lysis by fetal acetylcholine receptor-redirected T cells.
gan: Simon-Keller, K, et al.
Cyhoeddwyd: (2013)

The conformation of the main immunogenic region on the alpha-subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits.
gan: Fostieri, E, et al.
Cyhoeddwyd: (2000)

Acetylcholine Receptor and Muscle-Specific Kinase Autoantibodies
gan: Huda, S, et al.
Cyhoeddwyd: (2013)

Macrophage-Targeted Therapy: CD64-Based Immunotoxins for Treatment of Chronic Inflammatory Diseases
gan: Theo Thepen, et al.
Cyhoeddwyd: (2012-09-01)

The Structure, Function, and Physiology of the Fetal and Adult Acetylcholine Receptor in Muscle
gan: Hakan Cetin, et al.
Cyhoeddwyd: (2020-09-01)

Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen.
gan: Matthews, I, et al.
Cyhoeddwyd: (2002)

Autoantibodies in Chronic Obstructive Pulmonary Disease
gan: Lifang Wen, et al.
Cyhoeddwyd: (2018-01-01)

Immunotoxins: The Role of the Toxin
gan: David FitzGerald, et al.
Cyhoeddwyd: (2013-08-01)

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression.
gan: Gattenloehner, S, et al.
Cyhoeddwyd: (2007)

Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics and Therapeutics
gan: Konstantinos Lazaridis, et al.
Cyhoeddwyd: (2020-02-01)

Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis
gan: Berg Peter A, et al.
Cyhoeddwyd: (2010-10-01)

Autoimmunity to neuronal nicotinic acetylcholine receptors
gan: Maria Pechlivanidou, et al.
Cyhoeddwyd: (2023-06-01)

Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer
gan: Puri Raj K, et al.
Cyhoeddwyd: (2011-04-01)

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy
gan: Monika Bokori-Brown, et al.
Cyhoeddwyd: (2018-11-01)

Bouganin, an Attractive Weapon for Immunotoxins
gan: Massimo Bortolotti, et al.
Cyhoeddwyd: (2018-08-01)

Immunotoxin Therapy for Lung Cancer
gan: Li-Yi Xie, et al.
Cyhoeddwyd: (2017-01-01)

Prognostic Value of Circulating IGFBP2 and Related Autoantibodies in Children with Metastatic Rhabdomyosarcomas
gan: Elena Poli, et al.
Cyhoeddwyd: (2020-02-01)

Expression of foetal type acetylcholine receptor is restricted to type 1 muscle fibres in human neuromuscular disorders.
gan: Gattenlöhner, S, et al.
Cyhoeddwyd: (2002)

A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma
gan: Jinxu Fang, et al.
Cyhoeddwyd: (2016-01-01)

Immunotoxins: From Design to Clinical Application
gan: Robert J. Kreitman, et al.
Cyhoeddwyd: (2021-11-01)

Toxin and Immunotoxin Based Therapeutic Approaches
gan: Massimo Bortolotti, et al.
Cyhoeddwyd: (2022-01-01)

Antibody-Based Immunotoxins for the Treatment of Cancer
gan: Nurit Becker, et al.
Cyhoeddwyd: (2012-05-01)

Fetal acetylcholine receptor inactivation syndrome and maternal myasthenia gravis.
gan: Oskoui, M, et al.
Cyhoeddwyd: (2008)

Fetal acetylcholine receptor inactivation syndrome: A myopathy due to maternal antibodies.
gan: Hacohen, Y, et al.
Cyhoeddwyd: (2015)

Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway.
gan: Sudarshan Gadadhar, et al.
Cyhoeddwyd: (2013-01-01)

Autoantibody profiling of alveolar rhabdomyosarcoma patients unveils tumor-associated antigens with diagnostic and prognostic significance
gan: Elena Poli, et al.
Cyhoeddwyd: (2021-01-01)

Autoantibodies in the CNS: encephalopathy and potassium channelopathy.
gan: Beeson, D
Cyhoeddwyd: (2004)

Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features
gan: Park, K, et al.
Cyhoeddwyd: (2018)

Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder.
gan: Carolin Hoffmann, et al.
Cyhoeddwyd: (2018-01-01)

Antibody-Based Immunotoxins for Colorectal Cancer Therapy
gan: Laura Sanz, et al.
Cyhoeddwyd: (2021-11-01)

Development of Recombinant Immunotoxins for Hairy Cell Leukemia
gan: Robert J. Kreitman, et al.
Cyhoeddwyd: (2020-08-01)

Mesothelin-Targeted Recombinant Immunotoxins for Solid Tumors
gan: Brendan L. Hagerty, et al.
Cyhoeddwyd: (2020-06-01)

Immunotoxins: Targeted Toxin Delivery for Cancer Therapy
gan: Xin Mei, et al.
Cyhoeddwyd: (2019-08-01)

Immunotoxin: A new tool for cancer therapy
gan: Hossein Allahyari, et al.
Cyhoeddwyd: (2017-02-01)

Fetal Acetylcholine Receptor Inactivation Syndrome and Maternal Myasthenia Gravis
gan: J Gordon Millichap
Cyhoeddwyd: (2009-01-01)

Rhabdomyosarcoma
gan: Chaudhuri P, et al.
Cyhoeddwyd: (1980-01-01)

Myasthenia gravis seronegative for acetylcholine receptor antibodies in South Korea: Autoantibody profiles and clinical features.
gan: Kee Hong Park, et al.
Cyhoeddwyd: (2018-01-01)