Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli.
Dopamine neurons play a key role in reward-related behaviors. Reward coding theories predict that dopamine neurons will be inhibited by or will not respond to aversive stimuli. Paradoxically, between 3 and 49% of presumed dopamine neurons are excited by aversive stimuli. We found that, in the ventra...
| Principais autores: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2004
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| _version_ | 1826295692560171008 |
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| author | Ungless, M Magill, P Bolam, J |
| author_facet | Ungless, M Magill, P Bolam, J |
| author_sort | Ungless, M |
| collection | OXFORD |
| description | Dopamine neurons play a key role in reward-related behaviors. Reward coding theories predict that dopamine neurons will be inhibited by or will not respond to aversive stimuli. Paradoxically, between 3 and 49% of presumed dopamine neurons are excited by aversive stimuli. We found that, in the ventral tegmental area of anesthetized rats, the population of presumed dopamine neurons that are excited by aversive stimuli is actually not dopaminergic. The identified dopamine neurons were inhibited by the aversive stimulus. These findings suggest that dopamine neurons are specifically excited by reward and that a population of nondopamine neurons is excited by aversive stimuli. |
| first_indexed | 2024-03-07T04:04:57Z |
| format | Journal article |
| id | oxford-uuid:c5d4bfb3-9556-4d22-a6d7-f3b3583a86a1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:04:57Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:c5d4bfb3-9556-4d22-a6d7-f3b3583a86a12022-03-27T06:33:54ZUniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c5d4bfb3-9556-4d22-a6d7-f3b3583a86a1EnglishSymplectic Elements at Oxford2004Ungless, MMagill, PBolam, JDopamine neurons play a key role in reward-related behaviors. Reward coding theories predict that dopamine neurons will be inhibited by or will not respond to aversive stimuli. Paradoxically, between 3 and 49% of presumed dopamine neurons are excited by aversive stimuli. We found that, in the ventral tegmental area of anesthetized rats, the population of presumed dopamine neurons that are excited by aversive stimuli is actually not dopaminergic. The identified dopamine neurons were inhibited by the aversive stimulus. These findings suggest that dopamine neurons are specifically excited by reward and that a population of nondopamine neurons is excited by aversive stimuli. |
| spellingShingle | Ungless, M Magill, P Bolam, J Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
| title | Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
| title_full | Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
| title_fullStr | Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
| title_full_unstemmed | Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
| title_short | Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. |
| title_sort | uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli |
| work_keys_str_mv | AT unglessm uniforminhibitionofdopamineneuronsintheventraltegmentalareabyaversivestimuli AT magillp uniforminhibitionofdopamineneuronsintheventraltegmentalareabyaversivestimuli AT bolamj uniforminhibitionofdopamineneuronsintheventraltegmentalareabyaversivestimuli |