The pathophysiological role of TDP-43 in amyotrophic lateral sclerosis due to C9orf72 mutations

<p>Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative condition that affects corticospinal and spinal motor neurons and leads to death within 30 months of symptom onset in half of all cases. It remains incurable and treatment is supportive. The genetic and molecular understanding of AL...