Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.
In November 1999, a Médecins Sans Frontières team based in the southeastern part of Sierra Leone reported an increased number of cases of bloody diarrhoea. Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases. A total of 4218 cases of dysentery were reported in Kenema district from...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1797093817820643328 |
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| author | Guerin, P Brasher, C Baron, E Mic, D Grimont, F Ryan, M Aavitsland, P Legros, D |
| author_facet | Guerin, P Brasher, C Baron, E Mic, D Grimont, F Ryan, M Aavitsland, P Legros, D |
| author_sort | Guerin, P |
| collection | OXFORD |
| description | In November 1999, a Médecins Sans Frontières team based in the southeastern part of Sierra Leone reported an increased number of cases of bloody diarrhoea. Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases. A total of 4218 cases of dysentery were reported in Kenema district from December, 1999, to March, 2000. The overall attack rate was 7.5%. The attack rate was higher among children younger than 5 years than in the rest of the population (11.2% vs 6.8%; relative risk=1.6; 95% CI 1.5-1.8). The case fatality was 3.1%, also higher for children younger than 5 years (6.1% vs 2.1%; relative risk=2.9; 95% CI 2.1-4.1]). Among 583 patients regarded at increased risk of death who were treated with ciprofloxacin in isolation centres, case fatality was 0.9%. A 5-day ciprofloxacin regimen, targeted to the most severe cases of bloody diarrhoea, was highly effective. This is the first time a large outbreak caused by Sd1 has been reported in west Africa. |
| first_indexed | 2024-03-07T04:05:38Z |
| format | Journal article |
| id | oxford-uuid:c60c9611-1bc8-4dcb-8055-2be30c19de71 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:05:38Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:c60c9611-1bc8-4dcb-8055-2be30c19de712022-03-27T06:35:24ZShigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c60c9611-1bc8-4dcb-8055-2be30c19de71EnglishSymplectic Elements at Oxford2003Guerin, PBrasher, CBaron, EMic, DGrimont, FRyan, MAavitsland, PLegros, DIn November 1999, a Médecins Sans Frontières team based in the southeastern part of Sierra Leone reported an increased number of cases of bloody diarrhoea. Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases. A total of 4218 cases of dysentery were reported in Kenema district from December, 1999, to March, 2000. The overall attack rate was 7.5%. The attack rate was higher among children younger than 5 years than in the rest of the population (11.2% vs 6.8%; relative risk=1.6; 95% CI 1.5-1.8). The case fatality was 3.1%, also higher for children younger than 5 years (6.1% vs 2.1%; relative risk=2.9; 95% CI 2.1-4.1]). Among 583 patients regarded at increased risk of death who were treated with ciprofloxacin in isolation centres, case fatality was 0.9%. A 5-day ciprofloxacin regimen, targeted to the most severe cases of bloody diarrhoea, was highly effective. This is the first time a large outbreak caused by Sd1 has been reported in west Africa. |
| spellingShingle | Guerin, P Brasher, C Baron, E Mic, D Grimont, F Ryan, M Aavitsland, P Legros, D Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. |
| title | Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. |
| title_full | Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. |
| title_fullStr | Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. |
| title_full_unstemmed | Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. |
| title_short | Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. |
| title_sort | shigella dysenteriae serotype 1 in west africa intervention strategy for an outbreak in sierra leone |
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