Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort
<p><strong>Background & Aims:</strong><br /> Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested the...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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| _version_ | 1826307787681955840 |
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| author | Rothwell, J Murphy, N Bešević, J Schmidt, J |
| author_facet | Rothwell, J Murphy, N Bešević, J Schmidt, J |
| author_sort | Rothwell, J |
| collection | OXFORD |
| description | <p><strong>Background & Aims:</strong><br />
Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer cohort.</p><br />
<p><strong>Methods:</strong><br />
Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.</p><br />
<p><strong>Results:</strong><br />
Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.</p><br />
<p><strong>Conclusions:</strong><br />
Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.</p> |
| first_indexed | 2024-03-07T07:09:44Z |
| format | Journal article |
| id | oxford-uuid:c60cd5f8-3525-41fa-be8f-2d6d967ce613 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:09:44Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:c60cd5f8-3525-41fa-be8f-2d6d967ce6132022-06-06T07:56:48ZMetabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c60cd5f8-3525-41fa-be8f-2d6d967ce613EnglishSymplectic ElementsElsevier2020Rothwell, JMurphy, NBešević, JSchmidt, J<p><strong>Background & Aims:</strong><br /> Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer cohort.</p><br /> <p><strong>Methods:</strong><br /> Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.</p><br /> <p><strong>Results:</strong><br /> Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.</p><br /> <p><strong>Conclusions:</strong><br /> Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.</p> |
| spellingShingle | Rothwell, J Murphy, N Bešević, J Schmidt, J Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort |
| title | Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort |
| title_full | Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort |
| title_fullStr | Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort |
| title_full_unstemmed | Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort |
| title_short | Metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a European cohort |
| title_sort | metabolic signatures of healthy lifestyle patterns and colorectal cancer risks in a european cohort |
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