Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.

Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.

The major cause of mortality in patients with cystic fibrosis (CF) is lung disease. Expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene product in the airways is a potential treatment. Clinical studies in which the CFTR cDNA was delivered to the respiratory epithelia of...

Full description

Bibliographic Details
Main Authors:	Hyde, S, Southern, K, Gileadi, U, Fitzjohn, E, Mofford, K, Waddell, B, Gooi, H, Goddard, C, Hannavy, K, Smyth, SE, Egan, J, Sorgi, F, Huang, L, Cuthbert, A, Evans, M, Colledge, W, Higgins, C, Webb, A, Gill, DR
Format:	Journal article
Language:	English
Published:	2000

Similar Items

A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis
by: Gill, DR, et al.
Published: (1997)

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
by: Hyde, S, et al.
Published: (1993)

Apical CFTR expression in human nasal epithelium correlates with lung disease in cystic fibrosis.
by: Marit Arianne van Meegen, et al.
Published: (2013-01-01)

Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.
by: Gill, DR, et al.
Published: (2001)

Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.
by: Davies, L, et al.
Published: (2014)

Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis
by: Giulio Cabrini, et al.
Published: (2020-08-01)

MicroRNA Expression in Cystic Fibrosis Airway Epithelium
by: Catherine M. Greene
Published: (2013-02-01)

Nasal symbiont Staphylococcus epidermidis restricts the cellular entry of influenza virus into the nasal epithelium
by: Ara Jo, et al.
Published: (2022-04-01)

Future therapies for cystic fibrosis
by: Lucy Allen, et al.
Published: (2023-02-01)

Comparison of Ki67 Expression in Nasal Polyp Epithelium and Non-Polypoid Nasal Inflamed Mucosa
by: M Heshmati, et al.
Published: (2013-05-01)

Transcriptomic changes in the nasal epithelium associated with diesel engine exhaust exposure
by: E. Drizik, et al.
Published: (2020-04-01)

The effect of carbohydrates on the adherence of Pasteurella multocida to the nasal respiratory epithelium
by: CAROLINA GALLEGO, et al.
Published: (2021-07-01)

Emerging gene therapies for cystic fibrosis
by: Miah, K, et al.
Published: (2019)

Detection of CFTR transgene mRNA expression in respiratory epithelium isolated from the murine nasal cavity.
by: Holder, E, et al.
Published: (2010)

Cell-Based Therapeutic Approaches for Cystic Fibrosis
by: Pascal Duchesneau, et al.
Published: (2020-07-01)

Optimization of Nasal Liposome Formulation of Venlafaxine Hydrochloride using a Box-Behnken Experimental Design
by: Sulekha Khute, MPharm, et al.
Published: (2023-01-01)

The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction
by: Shunmei Chen, et al.
Published: (2023-07-01)

Inflammatory pathways are upregulated in the nasal epithelium in patients with idiopathic pulmonary fibrosis
by: Marc A. Sala, et al.
Published: (2018-11-01)

Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis
by: Sophie Gohy, et al.
Published: (2021-12-01)

Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.
by: Davies, L, et al.
Published: (2005)

Optimisation of real-time quantitative RT-PCR for the evaluation of non-viral mediated gene transfer to the airways.
by: Rose, A, et al.
Published: (2002)

Chronic Rhinosinusitis with Nasal Polyposis in People with Cystic Fibrosis
by: Jessa E. Miller, et al.
Published: (2023-10-01)

Effects of liposomal nasal spray with vitamins A and E on allergic rhinitis
by: Maria Lauriello, et al.
Published: (2020-06-01)

The nasal symbiont Staphylococcus species restricts the transcription of SARS-CoV-2 entry factors in human nasal epithelium
by: Jeong-Yeon Ji, et al.
Published: (2021-10-01)

Differential Expression Patterns of EGF, EGFR, and ERBB4 in Nasal Polyp Epithelium.
by: Chen Duan, et al.
Published: (2016-01-01)

DNA Methylation in Nasal Epithelium: Strengths and Limitations of an Emergent Biomarker for Childhood Asthma
by: Giulia Solazzo, et al.
Published: (2020-05-01)

Host Antiviral Response Suppresses Ciliogenesis and Motile Ciliary Functions in the Nasal Epithelium
by: Qianmin Chen, et al.
Published: (2020-12-01)

The Effect of Heparin on Antigen-Induced Mucus Hypersecretion in the Nasal Epithelium of Sensitized Rats
by: Takao Ogawa, et al.
Published: (2013-01-01)

Mechanistic Evaluation of the Impact of Smoking and Chronic Obstructive Pulmonary Disease on the Nasal Epithelium
by: Marja Talikka, et al.
Published: (2017-06-01)

Elexacaftor/Tezacaftor/Ivacaftor Accelerates Wound Repair in Cystic Fibrosis Airway Epithelium
by: Onofrio Laselva, et al.
Published: (2022-09-01)

Renal cystic disease proteins play critical roles in the organization of the olfactory epithelium.
by: Jennifer L Pluznick, et al.
Published: (2011-01-01)

Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA
by: Jana McCaskill, et al.
Published: (2013-01-01)

A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium
by: Annika Luukkainen, et al.
Published: (2018-11-01)

Trichosomoides nasalis (Nematoda: Trichinelloidea) in the murid host Arvicanthis niloticus: Migration to the epithelium of the nasal mucosa after intramuscular development
by: Fall E.H., et al.
Published: (2012-11-01)

Activity and interactions of liposomal antibiotics in presence of polyanions and sputum of patients with cystic fibrosis.
by: Misagh Alipour, et al.
Published: (2009-05-01)

Nasal septum and sphenoid sinus located adenoid cystic carcinoma
by: Eda Bengi Yilmaz, et al.
Published: (2017-03-01)

Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis
by: Zhongyu Liu, et al.
Published: (2020-05-01)

Nasal Septum Adenoid Cystic Carcinoma: A Case Report
by: Shu-Yu Tai, et al.
Published: (2007-08-01)

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis
by: Francis J. Gilchrist, et al.

Cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen positive, inconclusive diagnosis (CRMS/CFSPID)
by: Aditi Sinha, et al.
Published: (2021-09-01)